In 2008 Dr Ferid Murad, one of the Nobel laureates, gave a lecture on the miracle molecule to the University of Virginia. This lecture entitled “The Nitric Oxide Signaling Pathway” is now on YouTube.
The lecture, which is delivered to medical students and practitioners, is contains some fairly complex medical terms, but it is well delivered and easy listening. Dr Murad describes the ‘miracle molecule’, “What is unique about Nitric Oxide as a messenger….it is a free radical with an unshared electron. It is very permeable…..and so it can go where it wants, but not only does it act inter-cellularly as a messenger, it can leave the cell and govern the activity adjacent cells or even distant cells.”
Dr Murad describes how NO is made in the endothelium and other tissues and how three enzymes (NO synthases) turn Arginine into NO and L-citrulline. Addressing, in particular, endothelial dysfunction, hypertension, diabetes, atherosclerosis and tobacco use he plots the chain: elevated Asymmetric Dymethyl Arginine (ADMA) > elevated Reactive Oxygen Species (ROS) > decreased NOS cofactors > decreased NOS production > increased peroxymitrite formation with increased removal of NO.
The answer is, he concludes, L-arginine and antioxidant supplements. “It’s been shown,” he says, “certainly in animals and humans that these things improve vascular function and integrity.”
According to him in 2008 there were 80,000 research articles on Arginine Derived Nitric Oxide. Now there are over 200,000, but yet the importance of Arginine supplementation in preventing and mitigating so many illnesses remains unknown to all those people, who could benefit so much.