The study finds that persons over 50, who have returned from obesity to normal weight are about 60% more likely to die over the next eight years than those who have no history of obesity.
As the study itself stresses losing weight is not to be discouraged. However, the key point is that obesity causes illnesses, such as type 2 diabetes and cardiovascular disease. Indeed, these afflictions are a perfect storm. Obesity causes oxidization, type 2 diabetes causes oxidization, oxidization caused cardiovascular disease and cardiovascular disease leads to type 2 diabetes and often obesity. The causes of obesity, such as sugar, starchy carbohydrates, processed food, lack of exercise are also causes of oxidization of cholesterol in the arteries.
The conclusion must be that shedding weight should be accompanied by good nutrition. Good nutrition includes good supplementation, including anti-oxidants. Above all the message of these blogs is that a good form of L-arginine is the key to reversing the effects of previous oxidization, whether due to previous obesity or other causes. For those, who are obese, the reason to flush their arteries with Arginine Derived Nitric Oxide (ADNO) is just as compelling.
]]>The implication of this article was that the research showing serious side effects from statins (please see earlier blogs) including:
is somehow no more than a scare story.
Danish research is cited suggesting that while one in ten statin users in a trial number reported side-effects not all of these people were suffering statin related problems. There is (blogs passim) evidence that side-effects are under-reported. About 6 months ago a friend of mine, who is a vigorous 70 year old, complained that his ability to play tennis had suddenly declined seriously. He found that his mental function was reduced and when he eventually ran for a ball it was like trying to run in diving boots. I immediately asked him if he had recently been prescribed statins and, of course, his decline turned out to have coincided with statin use. After discussion he decided to stop his statins. A month later he reported that he was back to his old self. I recently met him again and asked how he was. He said he was alright, which did not sound that encouraging. It turned out that his GP had persuaded him to go onto a half-dose and he had agreed!
The Danish researchers allegedly asserted that 2% of heart attacks were explained by stopping statins and that [this sounds contradictory] “1 per cent of deaths from cardiovascular disease associated with early discontinuance of statins.” Putting aside the question of how it could possibly be said in any case that stopping statins had caused, or even resulted in failing to prevent, deaths from cardiovascular disease, there is a presumption here that statins have any significant benefits. The magnitude of the benefit to be derived from statins really depends on whether you believe that low cholesterol means that you are less likely to suffer ill health and death. The research shows the opposite. One day the statin lobby will be discredited in the world media, but given that there is so much money being derived from statins that day is probably still a long time off.
It is the oxidization of cholesterol and not the cholesterol itself that causes cardiovascular disease. The answer is not a drug with serious side-effects, but antioxidant supplementation. Avoid sugar, sweeteners, cooking by heating all oils (except coconut oil, which is a saturated fat like animal fat and butter – olive oil on salads is good, but don’t heat it), excess exercise and stress, air pollution, obesity (a little fat is good), processed foods, hydrogenated fat etc..
]]>In 1998 three great scientists, including Dr Louis J. Ignarro (pictured), won the Nobel Prize for their work on Arginine Derived Nitric Oxide (ADNO, or NO). In his book, “NO More Heart Disease”, Dr Ignarro writes, “By 1990, our experiments indicated that No is also the chemical messenger responsible for penile erections. Nerves in the erectile tissues release NO, dilating the blood vessels and initiating erections. The discovery soon led to the development and marketing by Pfizer of the drug Viagra……….. The success of this drug led some of my friends to call me ‘The Father of Viagra.’…..Our discoveries about blood pressure, blood clotting, and erectile dysfunction were only the start. Low levels of NO are associated with many of the most common diseases of mankind – from infections to malignancies to diabetic complications. We found that NO influences the functioning and wellbeing of the entire body.”
ADNO resists, reduces and reverses oxidization. Oxidative stress/cell damage from free radicals is the key problem to avoid. Research has shown that these are the underlying initiator of over 70 chronic diseases, including heart disease, cancer and diabetes (Davies, “Oxidative stress: The paradox of aerobic life,” Biochem Soc Symp, 61 (1995), 1-31).
Now a new study published in the “Journal of Clinical Endocrinology and Metabolism” seems to support earlier research showing that Viagra can assist in improving insulin sensitivity. Viagra started its life as a drug aimed at relaxing the blood vessels for people suffering from angina, but now it has another primary aim. This latest finding finding is said to be particularly important, because drugs presently deployed to stop patients moving from prediabetes to Type 2 diabetes can have side effects and in particular can themselves cause heart problems. Dr Nancy Brown (Vanderbilt University School of Medicine) is quoted in “The Times” as saying, “Because existing drug therapies to prevent type 2 diabetes can have negative effects on the heart or be of limited use in patients with kidney disease, strategies to prevent diabetes without adversely affecting the risk of kidney and heart disease could have a large impact on public health.”
It is, of course, no surprise that Viagra can assist in improving health, including resistance to diabetes, because it is derived from research into ADNO. Unlike statins, which I condemn for reasons set out in various blogs on this site including their side effect of causing diabetes, I have no serious criticism of Viagra. However, a key point is being missed here. It is ADNO that is active in Viagra in helping with diabetes. You do not need to take Viagra to obtain ADNO and for more than half the population of the world, namely women, Viagra can be quite an uncomfortable experience. The first thing anybody should do, especially if they have problems with diabetes or cardiovascular disease, is to consider a good L-arginine supplement, which will boost ADNO more generally than Viagra.
There have been very good results for sufferers from Type 2 Diabetes taking L-arginine supplementation. As long ago as 1994 it was established that oral Arginine supplements reduced collagen accumulation in the heart muscles of diabetic mice, which led to the conclusion that cardiac dysfunction in diabetes mellitus is due to impaired availability of Arginine Derived Nitric Oxide (ADNO) (Joffe et al, Circulation (abstracts), 96 (1997), 1518). More recent research (e.g. Hrabák and Kutor, “Arginine Amino Acid” page 33 et seq.) has linked the beneficial effect of Arginine on diabetes to the fact that it is an Arginase inhibitor. Arginase, which is, of course, a key liver enzyme, is directly implicated in cardiovascular disease, silicosis and asthma. In Type 1 Diabetes the impairment of endothelial ADNO is well established. The relationship between Arginase and reduced serum Mg2+ levels has been suggested to be a consequence of reduced insulin action (Bjelakovic, J.Basic Clin. Physiol. Pharmacol, 2009, 20, 319-334). Dr Louis Ignarro (above) concludes, “If you run tests on people with advanced diabetes, you would find that their endothelium is incapable of producing adequate amounts of [AD]NO….We know that nitric oxide can reduce blood pressure levels. ….We know that it can reduce the risk of diabetic retinopathy” (NO More Heart Disease”, pp 190-191).
]]>Jim Al-Khalili: “I guess much of your research has involved this amazing chemical, Nitric Oxide, not to be confused with Nitrous Oxide, laughing gas. Can you tell me about what that chemical is, what it does in the body?”
Professor Valance: “It was an amazing time in the 1980s, when two things happened. The first is that there was a discovery that the lining of the blood vessels, which up until that point had been thought of as an inert layer almost. People realized it was doing something very active, it was controlling how the blood vessels behaved. And then a couple of groups at the same time, one in the UK and one in the US, discovered that the substance being released was a gas, Nitric Oxide. It was really surprising. I mean it’s not a gas, it’s a solution, but fundamentally it is a gas and this controls the underlying blood vessel. …………..It turns out that it is important for the way blood pressure is controlled, it is important for the way the blood vessel system can accommodate fluid, it is important for the way things don’t stick to the blood vessel wall and so highly relevant for everything from high blood pressure right through to heart attack and changes the way we think about the vascular system actually.”
This programme should be available on the BBC website for some time to come. Professor Valance now works for Big Pharma.
]]>Two days later it emerged that the majority of people in the UK still support a sugar tax. Mr Graham McGregor, Chair of Action on Sugar, put the disappointing delay in publication of the report into context, by saying, "I don't think we need any more evidence." Quite right Mr McGregor! We have overwhelming evidence already that sugar is a leading factor in obesity, Type 2 diabetes and worst of all oxidization of cholesterol in the body.
If you have not done so already, please look at my monograph on Arginine and its benefits in combating oxidization and obesity by clicking on ADNO on this site.
]]>
Billy Bunter did not look after his cardiovascular health. He smoked, he was seriously overweight, he suffered serious stress at his school and he slept much too much.
Research has long linked life expectancy with hours slept. Now new research published in "Thrombosis and Vascular Biology" based on research in South Korea finds that 7 hours sleep is the optimum for good cardiovascular health (much the same as the previous more general studies relating to life expectancy). This latest study, which is based on 29,000 people, concludes that women are more at risk of coronary lesions than men as a result of poor sleep. Compared with 7 hours' sleep, men and women, who slept for 9 or more hours, were found to have 70% more calcium in their coronary arteries and those who slept for under 5 hours had 50% more.Billy Bunter did not look after his cardiovascular health. He smoked, he was seriously overweight, he suffered serious stress at his school and he slept much too much.
The theory propounded is that the underlying cause of damage is cortisol, the stress hormone. Chan-Won Kim, one of the researchers is quoted as saying, "Inadequate sleep is a common problem and a likely source of poor health, including visible signs of disease such as heart attack."
Readers will not have overlooked that L-arginine, which produces ADNO, boosts quality of sleep. ADNO diminishes naturally during sleep (hence the number of heart attacks at night) and so there is a double plus: first, you are more likely to have 7 hours of nourishing sleep and, secondly, ADNO relaxes and cleanses the arteries.
]]>British Celebrity Chef, Jamie Oliver, is rightly waging “absolute war” on sugar. Recent research (Van Rompay et al., Journal of Nutrition) shows that sweet drinks were linked with triglycerides and lowered HDL cholesterol. Dr Van Rompay is quoted as saying, “A clustering of risk factors including high triglycerides, low HDL-C, insulin resistance and obesity, especially if begun in childhood, puts one at higher risk of future cardiovascular disease.” (“The Times” 3rd September, 2015).
The key point is still being missed by many researchers and reporters alike, which is that sugar is a major cause of oxidization in the arteries. It is not poor old LDL cholesterol that causes its own oxidization, but rather it is factors such as sugar, smoking, stress, excessive exercise, obesity, diabetes, air pollution, heated oils (other than coconut) etc., which are the precipitators of oxidization of cholesterol. Clearly one important factor in maintaining good health is to avoid sugar in the diet, save as it appears in whole fruit and vegetables. Sugars in sweet drinks and processed food not only directly cause oxidization, but they also cause obesity and diabetes, which in their turn cause oxidization. The other factor is a nutritional one, which is to maintain a healthy diet and to maintain a high level of antioxidant supplementation. It was once possible to obtain sufficient anti-oxidation from diet, but please do not believe that dwindling number of nutritionists, who still say it is possible. Palaeolithic hunter-gathers were free from cardiovascular disease, cancer and many other common afflictions, but even those pursuing a ‘Palaeolithic diet’ cannot recreate the nutritional quality of our ancestors’ food (http://bit.ly/1bNkdv6).
]]>The Times article contains a timely warning about ‘juicing’. Juicing, especially of vegetables, is a very good thing. However, this voguish practice, promoted in such books as Jamie Oliver’s “The Juice Master Diet”, does require a word of caution. Whole fruits and liquidized whole fruits are very good for most people, but in juiced, as opposed to liquidized, fruit there is a real risk that fruit sugars, which are generally benign, become so concentrated as to be harmful; by juicing the body and pith of the fruit is diminished to that the concentration of sugars will be increased. So blend/liquidize the fruit, rather than using a juicer and all will be well. Professor Thomas Sanders (Ibid) is quoted as saying, “Obesity is the reason for the increase in type 2 diabetes and it is affecting mainly people in their late fifties and sixties, whereas the juice consuming population tends to be a younger age group.” Whilst I am not sure that I agree with the Professor on age groups, I am sure that he has missed one other obvious cause of type 2 diabetes amongst older people. That cause is statins. Sadly, but predictably, there is no mention of the benefits of L-arginine supplementation when it comes to Type 2 diabetes.
In one study half the patients with diabetes mellitus orally took a mere 2 grams of Arginine daily and the other half a placedo. After 3 months the Arginine group showed ‘significantly decreased lipid peroxidation (Lubec et al, “Free Radical Biology & Medicine, 22(1997), 355-357). Oral Arginine (equivalent daily dosage for an average human 7.5 grams) has been shown to reduce collagen accumulation in the heart muscle of diabetic rats (Joffe et al, Circulation (abstracts), 96(1997),I518) and in humans with Type 2 Diabetes ADNO was shown to increase levels of hormone insulin (Schmidt et al, Science, 255(1992),721-723). Recently Harak and Kukor published research showing the role of ADNO as an arginase inhibitor (arginase is implicated in cardiovascular disease, silicosis, asthma and diabetes - Bjelakovic et al., Basic Clin. Physiol. Pharmacacol, 20(2009), 319-334). They note, “Dietary arginine supplementation resulted in decrease of plasma glucose and lipid levels and in the improvement of insulin sensitivity in rats with chemically induced or genetically determined …diabetes. In contrast to drugs utilized in diabetic therapy, arginine supplementation also reduced adiposity and improved insulin sensitivity (Harak and Kukor, Arginine Amino Acid, 45-46).
Of diabetes Dr Louis Ignarro (Nobel Laureate for his work on ADNO) writes, “…we do know it [ADNO] can intervene to help prevent potential complications” and he advises diabetes sufferers, “We know that nitric oxide can reduce blood pressure levels. We know that it plays a role in erectile function. We know that it can reduce diabetic retinopathy. Nitric oxide can make a great and positive difference in your quality of life.” (“NO More Heart Disease”, 190-191)
Research has shown that oxidation/free radicals are the underlying initiator of over 70 chronic diseases, including diabetes and heart disease (Davies, “Oxidative stress: The paradox of aerobic life,” Biochem Soc Symp, 61 (1995), 1-31). L-arginine creates Arginine Derived Nitric Oxide (ADNO), which resists and reverses oxidation in the arteries (ADNO carries an extra electron to neutralize other free radicals, which lacking an electron can damage neighbouring atoms creating a domino effect). Dr Ray Strand sets out how he has successfully treated diabetes by (a) directing a diet that does not spike the blood sugars (proteins and fats basically good, sugar, processed carbohydrates, etc. basically bad), (b) using extensive antioxidant supplementation, and (c) recommending, in addition to antioxidants, chromium, vitamin E (this is, of course, an antioxidant), magnesium and vanadium ( “What Your Doctor Doesn’t Know About Nutritional Medicine May be Killing You”, 147-161).
]]>One such study was the Lipids Research Clinics Program, “Journal of American Medical Association” 1984; 251:351-364. Though not published in this pro-cholesterol reduction report was that there were three times as many deaths from suicide, homicide and trauma in the drug treatment group. Likewise in the research by Hulley et al., “Journal of the American Medical Association” 1992; 267: 100-102 it was found that in the then four largest studies into cholesterol lowering drugs deaths from suicide, trauma and homicides went up by 20%.
As long ago as 1992 Dr Ravnskov was able to conclude that “Lowering serum (blood) cholesterol concentrations does not reduce mortality (death) and is unlikely to prevent coronary heart disease. Claims of the opposite are based on preferential citation of supportive trials” “British Medical Journal” 1992; 305:15-19.
So to the blocking of coenzyme Q10, type 2 diabetes, thought and memory impairment, muscle pain, greater risk of mortality and many other serious side effects from lowering cholesterol by drugs should add violent death.
]]>This is very useful research, but it is not surprising, because it has long been known that aircraft noise is associated with increased cardiovascular disease (e.g. Hansell et al, BMJ 16.8.2013). The essential point is that cardiovascular disease, of which stroke is one of the fatal consequences, is caused by oxidisation of cholesterol particles in the arteries and veins. Oxidation/free radicals are the underlying initiator of over 70 chronic diseases, including heart disease (Davies, “Oxidative stress: The paradox of aerobic life,” Biochem Soc Symp, 61 (1995), 1-31).
What are the causes of oxidation within the body? The answer is well known:
* Stress
* Air pollution
* Smoking
* Food pollution
* Sugar
* Trans fats in processed foods
* Heated oils, except coconut oil
* Excessive exercise
If you live on a busy road, or under a flightpath, you are likely to suffer from both stress and pollution. It is therefore wholly unsurprising that those living in a noisy and/or polluted environment are likely to have greater cardiovascular disease.
The solution is really quite simple. Either move away, or, better still because even those in the deep countryside can suffer heart disease, take antioxidants. The most important antioxidant is, of course, L-arginine, which turns into Arginine Derived Nitric Oxide (please click on the ADNO page for more detail). Right back in 1989 Dr Daniel Steinberg published material in the New England Journal of Medicine (320 (1989), 915-924) suggesting that adequate intake of antioxidants prevented oxidization of cholesterol. In 1997 it was concluded that subsequent studies established that the higher the intake of antioxidants the lower the coronary artery disease (Ross “Atherosclerosis: An inflammatory disease,” New England Journal of Medicine, 340 (1999), 115-123).
We cannot all live lives free of noise, stress and pollution, but we can all take antioxidant supplementation.
]]>ShipShape TM
ARK 5 – INFERNO TM
THE FAT ANTAGONIZER!
The science behind the Product
By Chief Executive Scientist, Dr. Jeff Golini
ShipShapeTM Fat Antagonizer (Ark 5 – Inferno) is a completely unique innovation in weight control and burning fat. Just as with The ShipShape Shake (Ark 4 – Super Ark Food), it has taken over 7 years of scientific research and testing to develop from concept to finished product. Designed for weight control, Ark 5 – Inferno is a capsule that burns fat in the body and disperses it into the system to be used as energy. This ground breaking exclusive product is arguably the most affective and innovative fat burning weight control product that has ever been developed in the industry.
However, this ShipShape Fat Antagonizer capsule contains a magic ingredient that is completely unique and combined with an exclusive formulation makes up a fat burner for weight control that is totally exclusive to Arkworld International and burns fat away unlike anything else on the market today.
This patent pending magical ingredient is called Lyzme5®. So what exactly is Lyzme5® and how does the ShipShape Fat Antagonizer work?
Well, let’s take a look at the history and science behind this product, fat burning in general and this ground breaking magical ingredient in more detail...
History
The human body is composed of carbon, water, oxygen and nitrogen that is assembled and organized into infinite structural complexities. Of all our body’s complexities, seemingly simple fat is indispensable to life itself. It alone is responsible for compartmentalizing cells and organs, as well as insulating our neural network and preventing a biological ‘short circuit’. In other words, humans are essentially kept alive by fats.
Lipids (fats) are essential for life support. Lipids provide biological energy to burn, protect internal
organs, aide in nutrient absorption, and are the starting material for hormones and some vitamins. Lipids can be simple or complex. They come in a variety of forms, and are generally categorized into several families as fats, oils, phospholipids, sterols, triglycerides or waxes. All lipids share the same trait of insolubility in water and soluble in numerous organic solvents.
While a physical description of the lipid diversities is beyond the scope of this report, several members of two very important lipid families – the simple lipid cholesterol (high density lipoproteins [HDL], low density lipoproteins [LDL], and related fatty acids), and triglycerides – a complex lipid, have been linked to an ever increasing list of health concerns.
Good lipids gone ‘bad’
While the liver is capable of synthesizing essential lipid complexes from plant matter, humans usually overload this natural process by indulging in excesses of commercially available fats.
There are predominantly four types of fats in the foods. Saturated and trans fats (both of which are undesirable because of the way they are conjugated during absorption and metabolism) have been shown to raise low density lipoprotein (LDL) cholesterol (‘bad cholesterol’) levels in the blood; monounsaturated and polyunsaturated fats are not identified by our metabolic processes in the same manner, and do not appear to negatively impact LDL when consumed in moderation.
Excess calories (from fats, carbohydrates, and protein [to a lesser degree]) are all stored as fat (adipose tissue). The cycle of Hyperlipidemia (elevated serum cholesterol) begins with the synthesis of bile acid in the liver, from existing cholesterol, in response to choleric intake. As intake increases, more bile acid is produced. This material functions like an organic ‘soap’, forming a protective envelope around otherwise insoluble food fats (saturated and excess unsaturated fats), permitting digestion and metabolism. At the end of the cycle (in the ileum of the small intestine) they are ‘uncoupled’ (deconjugated) reabsorbed and recycled. This action increases the total amount of free cholesterol in the blood plasma. Storing of energy reserves
is a body’s survival mechanism. Excess carbohydrates (simple/complex sugars) and protein not burned are primarily converted to triglycerides and stored in fats cells. Excess of triglycerides in the plasma is called hypertriglyceridemia and is also linked to the occurrence of coronary artery disease.
Metabolic Syndrome, Hyperlipidemia and heart disease
Metabolic syndrome has a significant negative impact on morbidity and mortality. 25% of the adult population in the U.S., including as many as 60% of obese individuals, are reported to have Metabolic Syndrome. Elevated blood cholesterol (LDL and triglycerides) levels initiate arteriosclerosis and (potentially) hypertension. While it is not a universal association, hyperlipidemia is most often observed in conjunction with being obese.
Data from the National Health and Nutrition Examination Survey (NHANES) completed in 2001- 2004 showed that about two thirds of all adults in the United States were overweight and almost one-third were obese. According to a most recent cumulative study conducted by the CDC and NHANES, it was discovered that the number of cases of adult obesity has reached 68% (1). The CDC has estimated that obesity is fast approaching tobacco as the top underlying preventable cause of death in the USA. In 2000, poor diet including obesity and physical inactivity caused around 400,000 U.S. deaths, which is more than 16% of all deaths and the number two killer. That compares with 435,000 for tobacco or 18%, which is the top (self inflicted) underlying preventable killer.
In 2004, obesity mixed with inactivity increases the risks for the top two killers: all forms of cardiovascular disease (heart/disease and/or attack, cerebrovascular events – including stroke), and all forms of malignancies (2). As of 2004, the Journal of the American Medical Association listed ‘mistakes caused by the actions of health professionals’ the third leading cause of (preventable) death in the USA, beating out tobacco (3).
In addition, hyperlipidemia and obesity are strong risk factors for hypertension (today more than 50 million Americans have hypertension), diabetes, kidney disease, gastric related disease, gallbladder disease, osteoarthritis, sexual dysfunction (ED), sleep apnea and other breathing problems.
The Statin Drug paradox
Presently, the number one group of drugs for antilipidemic action are the Statin drugs. There is
considerable research that calls into question the metabolic friendliness of Statin drugs. This group of drugs, created approximately 20 years ago, acts by inhibiting 3-hydroxy-3-methylglutaryl-Co enzyme (HMG-CoA reductase). This enzyme is related to production of cholesterol. As production declines, a deficit in the total cholesterol pool forms causing the body to draw on its lipid reserves. The Statin drugs also have a secondary effect acting as an anti-inflammatory agent.
Despite manufactures claims that HMG-CoA reductase inhibition is the primary reason for the
cardiovascular benefit, there is now a growing body of evidence to suggest that it is not the case (4). By blocking cholesterol synthesis, it directly causes the depletion of other key biological components downstream such as, ubiquinol (coenzyme Q10), creatin and phosphorylation of various lipids, and muscle enzymes. Persistent muscle pain and weakness are the signs and symptoms of statin actions on these pathways.
Label warnings for the most common statin drugs warns users of the most common side effects such as: unexplained muscle pain and weakness, headache, muscle aches, abdominal pain, muscle weakness, nausea, diarrhea, muscle inflammation leading to kidney failure, blurred vision, bleeding, dizziness, (etc..). Some researchers are now questioning the potential cognitive impact statins are having (Alzheimer's, dementia, and confusion), long and short term, due to direct inhibition of the brain’s glial cell synthesis of cholesterol (5-6).
The Need
If you do not want to take a drug, your current choices are slim. The dietary supplement industry is loaded with slick ads and unbelievable claims backed up by nothing but marketing. These products have been under the eye of the FDA for years and we have seen may false claim suites, products adulterated with drugs to increase the outcome and high dose recommendations resulting in health issues.
Arkworld’s manufacturer has been in the supplement business since 1985 and is the current leader in product development and innovation. Now designing state of the art products exclusively for Arkworld since 2005, the Arkworld manufacturer’s track record speaks for itself with cutting edge developments and exclusive formulations over the last decade that are scientifically years ahead of the competition, such as The Pink Drink (Ark 1), Micro (Ark 2), The Purple Pill (X-Cell – Ark 3) and now the ShipShape Weight Control product line including The ShipShape Shake (Ark 4 – Super Ark Food)
and The Fat Antagonizer (Ark 5 – Inferno).
Arkworld has the best scientific research team in the world dedicated to developing and marketing the best ingredients in the World to support President and Founder Mark Landon’s dream of improving the health and quality of life for people and making this a better a world to live in.
So with this in mind, let’s take a look The Fat Antagonizers (Ark 5 – Inferno) magic ingredient Lyzme5®
and the science behind it…
What is the ingredient Lyzme5®?
Design:
The compound, referred to as Lyzme5(R), has demonstrated the propensity (in previous studies) to be directly involved in the breakdown, lysis and elimination of food-derived fats as well as assisting in the reduction of liver-derived lipids. This is an exciting discovery, which will aid the body in lowering overall cholesterol and triglyceride levels.
Structural importance:
Lyzme5® can be classified as a unique trimethylated material. This compound’s unique trimethylated structure makes it highly important in methyl group metabolism. Many important chemical events in the body are made possible by the transfer of methyl groups. For example, genes can be switched on or off (methylation or de-methylation) in this way, and cells-to-cell communication (i.e. membrane receptor site activation/competition) can be carried out via methylation.
Functional mechanism:
Dietary lipids are transported to the liver by lipoproteins called chylomicrons. In the liver, fat and
cholesterol are packaged into lipoproteins called very low density lipoproteins (VLDL) for transport through the blood to the target tissues.
There are several mechanisms for Lyzme5®’s actions in the reduction of overall cholesterol. The first is the ability to reduce hepatic related lipids. Lyzme5(R) acts by interfering with hepatic storage and or lysis of lipids, assisting in ‘chaperoning’ lipid molecules from the liver, back into the blood stream. With an exercise program your body can now burn these lipids for energy, resulting in a reduction of body fat.
The second mechanism of cholesterol reduction is through inhibition of cholesterol synthesis in the liver. Lowering cholesterol in hyperlipidemic individual is the first step in slowing the development of coronary artery disease.
Summary
The ShipShape Fat Antagonizer (Ark 5 – Super Ark Food) is a fat burning capsule with an exclusive pioneering formulation unlike anything designed for weight control before. With a patented magic ingredient and a science years ahead of its time, the results and much needed help for those wishing to control or lose weight safely and effectively will be nothing short of amazing.
This makes Arkworlds ShipShape Fat Antagonizer (Ark 5 – Inferno) the most bio available and affective fat burner ever created, not only because of its magical pioneering ingredient but also as with the ShipShape Shake (Ark 4 – Super Ark Food) it deliveries the highest quality and absorbable nutrition at a cellular level into the body. The results speak for themselves!
The ShipShape Fat Antagonizer capsule – The most scientifically advanced weight control and fat burning capsule ever to be designed. Simply light years ahead of the competition!
Get into ShipShape and feel the difference!
This product is best used in conjunction with the ShipShape Meal Replacement Shake (Ark 4 –
Super Ark Food) as part of the ShipShape Weight Control Product Range.
Arkworld’s ShipShape Fat Antagonizer (Ark 5 – Inferno) with Lyzme5 is an exclusive formulation with national and International patents pending. ShipShape is a registered trademark of Arkworld.
All rights reserved.
* * * * * * *
Literature Cited
(1) Ogden CL, Carroll MD, McDowell MA, Flegal KM. Obesity among adults in the United States – no
change since 2003—2004. NCHS data brief no 1. Hyattsville, MD: National Center for Health
Statistics; 2007.
(2) National Vital Statistics Report, Volume 53, Number 5; October 2004.
(3) Journal Of The American Medical Association; Starfield,B; 284(4):483-485; 2000.
(4) Shovman. Immunol Res,25(3); 2002.
(5) Pfrieger. Science, 9 Nov, 2001.
(6) Muldoon. Am J Med, 108(7); 2000.
]]>ShipShape TM
ARK 4 – SUPER ARK FOOD TM
The science behind the Product
By Chief Executive Scientist, Dr. Jeff Golini
ShipShapeTM (Ark 4 – Super Ark Food) Nutritional Shake Mix is a Meal Replacement that is unlike any other on the market today taking over 7 years to develop from concept to finished product.
Designed for weight loss and healthy nutrition the ShipShape Shake is a complete healthy meal in a glass with an exclusive and balanced blend of protein and key nutrients. Containing 210 calories per meal of the highest quality nutrition and exclusive Ark blends it is arguably the healthiest and most affective Meal Replacement Shake that has ever been produced in the industry.
However, that is only half the story as the ShipShape Shake contains a source of protein that is completely unique and combined with the nutritional blend that makes up the meal replacement is totally exclusive to Arkworld International. This patent pending protein is called ProtaLyn®
(Enzymatic Hybrid Protein) which has a higher efficiency rate than any other protein on the market.
What does that mean and what exactly is ProtaLyn?
Well, let’s take a look at the science behind the product and this ground breaking source of protein in more detail...
What is ProtaLyn?
The Arkworld scientists have worked long and hard to develop a perfect protein by finding a way to pump more of this muscle-building compound into your body through “Hybrid Enzymatic Peptide
Processing”TM. This brand new protein technology is derived from our patent pending process using enzymatic reaction during the liquid phase before drying. The ‘Hybrid’ is formed by the reaction of milk and grain protein extracts resulting in the finished product called ProtaLyn®.
What Is Protein And Do Humans Need It?
The word protein comes from the Greek word proteios. Proteins were first discovered and named by the Swedish chemist Jons Jakob Berzelius in 1838.
Proteins are organic compounds made up of amino acids that are arranged into a linear chain and joined together by peptide bonds. These peptide bonds are formed between the carboxyl and amino groups of adjacent amino acid residues. The amino acid sequence of a protein is fully defined by the sequence of a gene. This gene is encoded in the genetic code which specifies 20 standard amino acids.
Many proteins are also enzymes that can catalyze biochemical reactions and are crucial to human metabolism. These proteins must first be broken down into free amino acids before this process can take place, which is why it is important that your protein source be digested and assimilated easily.
The following eight amino acids are considered essential for humans. They are phenylalanine, valine, tryptophan, theonine, isoleucine, methionine, leucine and lysine. They are called essential not because they are more important but because our bodies cannot produce them, making it essential to obtain these eight from the diet.
In addition, the amino acids arginine, cysteine, glycine, glutamine, histidine, proline serine and tyrosine are considered conditionally essential, which means they are not normally required in the diet but must be supplied exogenously to specific populations that do not synthesize them in adequate amounts. The rest are called non-essential because our body can synthesize them.
The bottom-line is that Protein is essential to human life; it cannot be sustained without it. The higher the quality of protein, the less you need - that is the key to the protein game.
How Much Protein Do You Need?
The U.S. Food and Drug Administration currently recommend that protein make up 10 percent of the total calories you consume each day. Since protein has 4 calories per gram, in a 2,000-calorie diet, that would allow for 50 grams of protein. Meanwhile, the U.S. national average consumption of protein is about 90 grams daily. However, athletes need more than the average human. Scientists have determined that an athlete (depending on the sport) needs about 1 gram per pound of body weight. (2.2 grams per kg of body weight)
Why Is ProtaLyn® A Better Protein Choice for ShipShape?
Due to the absorption rate of ProtaLyn®, less is more. No more formulating a protein, meal
replacement or diet powder with 50 grams of protein. Your body can only utilize so much every three to four hours. Since ProtaLyn® is absorbed and digested very quickly; all you need is 15-24 grams per serving (pending your weight & type of sport), making this much more cost effective than typical Whey Isolate or Whey Concentrate. This gives ShipShape (ARK 4 – SUPER ARK FOOD) not only the best value on the market but a scientific edge over everyone else in the industry.
If you are looking for a new protein source, ShipShape (Ark 4 – Super Ark Food) containing
ProtaLyn® is your answer. It also allows us to put on the ShipShape labels Patent Pending, giving you as distributors a HUGE marketing advantage over other protein sources. This sets up Arkworld light-years ahead of the competition utilizing the most advanced science known to man.
ProtaLyn® protein is also completely stable under hot and cold conditions.
How Is ProtaLyn® Made?
This biologically active protein represents the next generation of high end protein powders. The Arkworld’s manufactures Dairy Division have spent many years in continued research to develop high quality, great tasting protein which is what has lead to the development of ProtaLyn® and ShipShape.
‘From the very beginning of Arkworld President & Founder Mark Landon told Dr Jeff Golini that one
day he wanted to develop the greatest and healthiest weight control product range in the industry and
with the ShipShape weight control product range now developed that dream has become reality. The
ShipShake Shake (Ark 4 – Super Ark Food) and the ground breaking Fat Antagonizer or ShipShape
(Ark 5 – Inferno) have taken 7 years to develop and over 12 years since Mark Landon had the
original idea.’
In any process you must begin with the highest quality ingredients to end up with superior finished goods. You’ve heard this one many times before, but it is worth repeating again:
“Garbage in, Garbage out”
This simply means if you start with low quality raw material you will get a low quality finished product.
USDA prime choice milking cattle are chosen for the milk source. Special care is taken with
everything from their feed, to how they are handled.
No steroids are used on these cows, nor is any GMO food. (GMO stands for Genetically Engineered Organisms). Second, we take high quality, home grown grains that are organically grown without pesticides and are non GMO. These raw materials start the process. We hand raise cattle from birth, on a special high protein & vitamin diet. When the cattle have reached the right age for milking, they are milked under controlled USDA conditions. The milk is immediately loaded into temperature controlled stainless steel transfer trucks. Upon arrival at our State of the Art filtration & ionization
plant, every step of the process is monitored for quality.
Whey Peptides are chains of amino acids derived from longer whey protein molecules. From an intense study published in 1989 in France on this whey peptide process, the following was reported:
* More insulin like growth factor (IGF-1) was released
* An increased nitrogen retention in the muscles
* More intracellular anti-aging antioxidants present
(Journal of Parental & Internal Nutrition, 13:382 1989)
This brilliant study proved that whey peptides out performs regular whey protein, casein, soy, egg or milk. The categories of performance were higher nitrogen levels, improved anabolism, muscle size increases, & better over-all growth and protein synthesis. For over a decade now the Arkworld scientists have been aware of how to theoretically boost metabolic response to protein by molecularly altering the peptides structures. But, it was not until about 3 years ago that the break-through started to happen with our theory. We call this breakthrough, “Hybrid Enzymatic Peptide Enzyme Technology”.
With our new Patent Pending process our scientists have been able to use what is commonly called ‘enzyme production’ to achieve the impossible. In this process, special enzymes are chemically used to cleave the long whey protein molecules into the New Hybrid Peptides. This new process means:
* Increase in Nitrogen Utilization & Retention
* Improved Endocrine Hormone Response
* Imported increase in Immune Function
* Increase in Gastrointestinal Health
* Increased Muscle Growth
* Increased Digestibility and Absorption
During this first process, enzymes are added and the mix processes as the milk ripens. The dairy whey is then removed from the mix and transported to another holding tank. The following steps now take place:
1). Casein is removed to secure proper filtration
2). Separation of cream to reduce the fat content
3). Heat treatment to control bacteriological quality
4). The addition of high quality grain extracts
5). Additions of pre-treatments
6). pH adjusted
The second step then requires this mix to sit, mature, and then chill for 24 hours before moving into filtration. Once the required peptide response is achieved, the liquid mix moves into ultra filtration, which removes the remaining fat, etc., to a concentration of around 75% protein solids by dry measurements.
High heat and denaturing processing are the quickest and cheapest ways to dry protein. However, it should also be noted that extreme heat is the worst drying process for proteins because it ruptures (“denatures”) and reforms the natural protein bonds into cross-links. This slows down the digestion and absorption process because these cross-linked proteins have thousands more bonds for the enzymes in your intestines to break down. Because it takes longer for the amino acids to reach the muscles, it causes about a 65% less nitrogen retention.
Some proteins that are commonly processed with extreme heat are; egg whites, lactalbumin, casein, & whey protein. Our scientific processing techniques use "State of the Art" technology and equipment, allowing us to bypass this deadly heating process by using a cold high speed air chamber drying technique. In these large chambers, the ionic cold high speed air processing blows off all the excess water, leaving us with a finished powder called ProtaLyn®.
This process results in the most bio-available protein ever produced!
How Are Proteins Rated?
In order to explain why ProtaLyn® is the ultimate protein and why as a result ShipShape Ark 4 –
Super Ark Food is the ultimate Meal Replacement Nutritional Shake Mix ever made, it is first
important to understand how proteins are rated. I am not talking about slick marketing ads that say they have the best protein or some ridiculous made up protein score, rather I am talking about real science and testing as outlined by the FDA.
Here are the most commonly used protein testing categories:
A). Biological Value (BV)
Measures the amount of nitrogen retained in comparison to the amount of nitrogen absorbed.
B). Net Protein Utilization (NPU)
The ratio of the nitrogen used for tissue formation versus the amount of nitrogen digested.
C). Protein Efficiency Ratio (PER)
Measures the ability of a protein to support growth by representing the ratio of weight gain to the
amount of protein consumed.
D). Amino Acid Scores (AAS)
A chemical technique that measures the indispensable amino acids present in protein and compares
the values with a reference protein. The protein is rated based upon the most limiting indispensable
amino acid
E). Protein Digestibility Corrected Amino Acid Score (PDCAAS)
The amino acid score with an added digestibility component.
F). Protein Digestibility (PD
A test to measure how well protein is digested.
The Test Results Are In!
PROTEIN QUALITY TESTS COMPARISON SUMMARIES
Protein type |
DDCAAS |
AAC |
PER |
BV |
PD |
WPC |
0.90 |
1.05 |
2.9 |
93.8 |
96.9 |
Casein |
1.00 |
1.00 |
2.5 |
88.0 |
99.0 |
Soy Protein Concentrate |
1.00 |
0.99 |
2.2 |
4.0 |
95.0 |
Beef |
0.92 |
0.94 |
2.9 |
80.0 |
98.0 |
Eggs |
1.00 |
1.21 |
3.8 |
88.0 |
98.0 |
ARK ProtaLyn |
1.00 |
1.10 |
3.0 |
96.4 |
99.0 |
Summary
On average, the ShipShape protein - ProtaLyn® outperformed all other proteins sources. These tests show that you can use less ProtaLyn® than whey protein concentrate, casein, soy protein, beef or eggs, because ProtaLyn® is absorbed and digested very effectively. Smaller amounts are all that is needed, making this the perfect protein choice above all other proteins on the market.
This makes Arkworlds ShipShape Shake (Ark 4 – Super Ark Food) the most bio available and affective meal replacement ever created, not only because it uses a protein that out performs all other proteins but also because it deliveries the highest quality and absorbable nutrition at a cellular level into the body. The results speak for themselves!
The ShipShape Shake – The most scientifically advanced weight control meal replacement and protein nutritional shake ever designed. Simply light years ahead of the competition!
Get into ShipShape and feel the difference!
This product is best used in conjunction with the ShipShape Fat Antagonizer capsule (Ark 5 –
Inferno) as part of the ShipShape Weight Control Product Range.
Arkworld’s ShipShape Shake (Ark 4 – Super Ark Food) with ProtaLyn is an exclusive formulation with national and International patents pending. ShipShape is a registered trademark of Arkworld.
All rights reserved.
* * * * * * *
References:
1). BioCeuticals Research & Development Lab, “Protein Scores”, 2008
2). Atlas Bioscience, “Amino & Protein Digestion”, 2006
3). Medical University, Sofia Facility of Pharmacy, Amino & Protein Cell line studies, 2007.
4). Armitage, P. 1973, “Statistical methods in medical research. Halsted Press, John Wiley and
Sons Inc. New York
5). Food and Agricultural Organization/World health Organization Expert Committee. 1973
“Energy and protein requirements”, World health Organization, Tech. Repr. Ser. No. 552.
Geneva
6). Food and Agricultural Organization. 1970. Amino acid contents of foods and biological data
on proteins. Nutr. Stud. No. 24. Food and Agricultural Organization, Rome.
7). Forsum, El, and L. Hambraeus. 1977 Nutritional and Biochemical studies of whey products.
8). Hambraeus, L., E. Forsum, L. Abrahamsson, and B. Lonnerdal. 1976. Automatic total
nitrogen analysis in nutritional evaluations using a block digester. Anal. Biochem. 72:78
9). Protein Advisory Group Guideline No. 8. 1975. Protein-rich mixtures fr use as
supplementary foods. PAG Compedium, Vol. F1:631
10).Biological Evaluation of Grain Supplemented by a Whey Protein Concentrate or Whey
Cheese on Growing Rats, Elisbet Forsum, 1979 J. Dairy Sci 62:1207-1210 Sweden
]]>
Rifleman A. J. Seabrook 3036 (No. 3 Hut)
29-7-15. We left Hatfield over a regiment strong arriving in Liverpool in the afternoon. Our route from the station (Lime Street) to the docks were crowded with people who gave us a tremendous reception. The women and children carried our kitbags and brought out tea etc.. On reaching the docks we at once boarded to “Aquitania” where already on board was most of the other regiments. Half the “East Anglian Division” sailed on her. Before settling down all rifles and helmets had to be stacked in racks after which we had our first meal since breakfast and turned in for the night.
“Mauritania” to dock. During day lifebelts were issued to every man and we were told off for duties. I was put in the mess for the duration of the voyage. Late that night we sailed and by morning we were well on our way.
For a few days no land was seen and only other craft consisted of our escort of destroyers. On arriving near Gibralta our escort gradually dropped away. We passed through the Straits near the African shore without stopping. Now plenty of craft were to be seen – mostly trading coasting vessels. The weather was now getting very hot and we spent our spare time on deck basking in the sun. Our berths were too stuffy at nights so most of us slept either on the upper decks or in the corridors and passageways. We now passed some lovely islands off the African shore.
5-8-15 Arrived at Lemnos Is.. Here lay the Allied Fleets making a grand sight. Stopped here for four days and saw the 29th Division pass on their way to Suvla Bay.
from Aquitania to “Carron” and worked right through the night.
9-8-15. Steamed up to Mudros on “Carron.” We now heard the guns plainly. Slept that night on the boat.
Here were thousands on men and mules including the R.N.D. our own and also Indian Troops.
troops were who landed there days previously. Slept that night in a gulley and I was on guard from 2 a.m. to 4 p.m.. As dawn came we found we had camped in the midst of the remains of a fierce fight as the unburied bodies shewed. It was our first taste of the horrors of war.
expedition. For the rest of the day and through the night we were unloading stores from the lighters.
12.8.15. Engaged in heavy fatigue work and bathing in spare time.
13.8.15. In the morning shell after shell was dropped on base. Many of the mules stampeded and several casualties in our own regiment. Left for the hills in afternoon and got our first real experience of bullets. Several casualties resulted including Sgt. Gardiner of my own platoon who was hit in the head.
14-8-15 In the morning we made an excursion through One Tree Gully. On reaching our position we dug ourselves in but was so heavily shelled we returned to base. A few casualties. Berg in my platoon wounded in the head.
In the afternoon we fell in again for as we thought a small fatigue job but were marched up to One Tree Gully where we lied down until it became dark. We then marched in single file over the crest of the hill into the valley which separated us from the Turks positions.
Our duty now was to dig a line of trenches in this advanced position to make a turning or flanking movement. As soon as we commenced digging a hail of bullets were discharged at us but with little damage as we took cover behind large boulders and rocks, which abounded. At 12 o’clock midnight we had got down fairly deep by the aid of sandbags and boulders had erected a pretty solid barricade. The order now came to file off towards One Tree Gully. Twenty men including myself and my pal were detailed from their company to guard the trench until morning, and were told we should be relieved at 6 a.m. in the morning.
15/8/15 Sunday The Battle of Kidney Hill 6 a.m. came but no relief arrived. None of us had water left because we had no idea when starting from base that we would be away for any length of time, so drank it during the evening when digging. The sun got fiercer and fiercer as the morning advanced. About 12 midday the Bedfords advanced and told us we were enfillated (enfilade: outflank for the purpose of shooting down the defensive line) by a large force of Turks. They then went to our left and ran into very heavy fire. Dozens of wounded came walking and crawling back to beg us for water. Of course we could do nothing but bind some of them up. Our officer now decided to advance and join the Bedfords. We advanced over the hill, at once coming under heavy shrapnel and rifle fire. Now everything was in confusion; men dropped rapidly, but very little ground was gained. We took up positions behind large rocky boulders, and opened up independent fire. This went on for some hours until we were forced to retire. I got back into the gully where wounded were lying about in heaps. The Brigadier Major now appeared on the scene getting some men from and regiment he could; in all, he got a party of 150 men (of which I was one), which party he divided into two, then ordered us to take the hill, viz. Kidney Hill. We charged, with the bayonet, although many men dropped before we reached the Turks. When within 20 yards of them, most of them fled, while the rest were either killed or taken prisoners. Now, the biggest mistake of all the mistakes of that day took place. The rest of the division below, not realising that we had taken the Hill, commenced to fire on us, instead of advancing to reinforce us. The few of us that were left had to take what cover we could to escape the fire of our own comrades. Darkness now came and put an end to the firing on both sides. On counting up we found a dozen fellows (from the Bedfords chiefly) and a few from the 10th, 11th London Regiment and one officer (A Bedford Captain). For some long time we laid there with nerves up to the highest pitch. All round we could hear the wounded calling for water and stretcher bearers. Of course, no help could be given to these poor fellows, many of them lying for several days before expiring. We now cautiously felt our way along the Hill trusting to meet the remains of the other party which had advanced on the right; this we did, meeting a party of men under Capt. Clerk of our Regiment. We now decided to dig ourselves in, as deeply as possible, before dawn and hold the Hill and a few stragglers who now came in, had nearly 100 men in the trench which was less than a foot in depth. On looking round I was delighted to see my pal Ted Wilson, whom I had not seen since the beginning of the battle.
16.8.15 All day we lay flat on our faces gasping for water, while a terrific sun poured down. Several casualties occurred owing to shrapnel fire. In the evening we took up another position and sent a fatigue party down for water which was wanted badly. A few cans of water were brought back.
17.8.15. We spent the day the same way as the previous day. In the evening, we could hold out no longer, so gave the position up, filing off as silently as possible to One Tree Gully. In those few days we learnt the great value of water and also that a soldier’s bravery cannot surmount the blunders of the Headquarter Staff.
18.8.15. Decided to stay in One Tree Gully for a time, as original base was being heavily shelled. The day was spent on fatigue work, viz. in getting up water supplies. The roll was called this day to which nearly 400 answered out of the Regiment. In the evening a party went down to Suvla Bay where we had a dip by moonlight returning just before dawn with a supply of water from the “Old Turkish Well”. This dip was the 1st wash I had had since the previous Saturday morning.
19.8.15. Day engaged in fatigue duties. Nigh time carrying water to firing line.
20.8.15. Again engaged on fatigues. In the evening went on observation duty for 24 hours. The guard was fairly quiet except for snipers who worried us.
22.8.15 Left for old base at Suvla where we slept until daybreak.
23.8.15. In the morning marched with full pack and water can each across the hills to form a new base, and get a rest. Dug ourselves in near the sea-shore, but was shelled out, and moved higher up the hill. Had a good dip in the sea.
24.8.15. In afternoon I went to the old base for stores, and got caught in a terrible rainfall. The shelling was still very heavy.
25.8.15. Quiet. Water supply scarce. We waited two hours at a spring with bottles.
26.8.15. Got up early and went for water for breakfast. Fatigue duty to base. At midnight we shifted with full pack to Alli Ba, a most exhausting struggle through the old base and across Salt Lake. We turned in at 5 a.m. after having dug ourselves in.
27.8.15. Quiet morning. In the afternoon we dug trenches for 4 hours. I wounded by shrapnel. In the evening we shifted ¼ mile up the beach.
28.8.15. This day very quiet except for I hour’s heavy sheling. Had a dip. There was plenty of food to be had. Another move at 8.15p.m. We arrived after a most exhausting march within two miles of Anzac.
29.8.15. Sunday. Rested on side of hill but was worried greatly by a machine gun sniper who caused eleven casualties. Here there were swarms of flies which prevented us from sleeping.
30.8.15. At dawn we moved higher up into the hills to escape snipers and dug ourselves in. In the evening we moved off and were digging a trench until dawn (eight hours). I felt half dead by morning. All the time were under heavy fire. The Turks were using starlights to shew our position up.
31.8.15. Went down for supplies. Ted went on observation duty. In our absence several shells came over in quick succession. Over a dozen of my company was wounded while Sgt. Baber and Captain Whitehead were killed. On going to my dugout to get my equipment found it full of shrapnel so Ted and I congratulated ourselves. We moved lower down the hill and dug fresh dugouts. We were now next to an Indian encampment. During the time we were here we got on well with the Indians who gave us chapattis and currie. In the evening resumed digging the previous nights trenches which were now deep enough to be safe to work in again working eight hours on end. Felt tired out.
1.9.15. We had a quiet morning went into Anzac for water (two miles) and had a dip. Resumed digging in evening but for four hours this time.
2.9.15. Fairly quiet day. A few fatigues. Still troubled by snipers. In the evening finished the digging.
3.9.15. Went to Anzac for supply of water had a dip. In the evening we moved into the gully or dried river bed. The camp where we were now called Finsbury Vale.
4.9.15. Again went to Anzac for water. This day 3 men were wounded in my own company. In the evening we marched up into firing line to relieve the Bedfords. We now spent a week in the firing line. At night time no one was allowed to sleep. In the day time we took it in turns to guard the trenches and observe the Turks movements while the rest went into dugouts just behind the trenches. It was not possible to sleep however as the swarms of flies plagued us and the sun was broiling.
8.9.15. Mail reaches us. There were four letters for the platoon mine
had gone astray. Feeling pretty well. Several men had collapsed. Ted changed a pair of socks for some jam. I got some for a shirt.
9.9.15. We had some fresh mutton sent up which was the first fresh meat since landing. More men collapsed this day.
10.9.15. Very heavy artillery duel between our fleet and the Turks. In the evening a charge was made by the Division on our right. We were out of that except for supporting them with heavy rifle fire.
11.9.15. We were relieved by the Bedfords and moved back to Finsbury Vale. We found the gully just as dangerous from snipers as when we left in fact we lost more men at Finsbury Vale than when in the firing line. In the evening of same day forty eight men from our Battalion including Ted and I were sent to join the Colonials. We were tired out when we started and had a terrible drag with full pack up the hills. On arriving at the Colonials encampment. The New Zealanders gave us tea and rice. The men from my company (C 6-7) was attached a trench manned by Mahoris (Maoris) with a N.Z. Captain
12.9.15. Sunday. Found we were less than two hundred yds from the Turks and watched them through the periscope digging and sniping when we got the chance. The Mahoris were a jolly set of fellows and seemed well educated. In the evening they were relieved by Australians from Egypt. I got a few hours sleep the first for a week. Today the Australian Cpt. Was shot through mouth and neck when looking over the parapet (Editor: Lieutenant F E Jensen, 28th Battalion (Western Australia) was shot through the face in the front line. Jensen subsequently died of his wounds. This was the battalion's first day in the Gallipoli trenches).
13.9.15. Australians left. The relieving Australians lost several men from shrapnel.
14.9.15. Weather cools and feeling pretty queer.
15.9.15. Left trenches in evening and moved into gully and laid down for the night. The rain came on and poured all night. In the morning we were half buried in wet sandy soil. In afternoon we left Colonials to rejoin our Regiment. We had only a few casualties while with the Colonials. The march back was a terrible one several collapsed. When halfway back I collapsed myself. Want of sleep and food was taking effect. After resting for an hour I followed the track back to Finsbury Vale passing half a dozen other chaps lying in the road. The stretcher bearers were sent out after them. (Editor: the more fortunate Corporal R.D. Doughty recorded, “Rained like blazes last night, but our dug-out proved quite water proof although the mud was particularly sloppy when we got out this morning. Have just rec. orders to expect a move any old time now to go to some new landing, so I suppose things will be extra brisk soon. HURRAH!”)
16.9.15. Tried to get up with my pack, but could not manage it. Was sent to the doctor and with a party of other sick men marched down to the Beach Hospital with full pack. We straggled into Anzac where was examined and sent to the Hospital Ship the “Somali”. The voyage to Malta was vague as I was delirious the same day. (Editor: it would appear that Rifleman Seabrook had enteric fever. He later recounted that the orderlies were tossing the dead over the side. When they reached him he heard them opine that he was dead and found to his horror that he could not move. As they took hold of him to remove him from the ship he managed to wink an eyelid and by great good fortune this was noticed)
22.9.15 Arrived at Imtafa Hospital, Malta. I was now in bed until I vowed I should never go to bed anymore.
14.11.15 Got 15 letters mostly from Peninsula.
16.11.15 Out of bed for half an hour.
5.12.15 Sailed on “Re’ d’Italia”.
6.12.15 Called at Sicily to land Red Cross Nurses and bedsteads. A new hospital for Australians was being formed there.
10.12.12. Gibralta we made a two hour stay.
11.12.15 Entered Bay. Weather now cooler and sea very rough.
13.12.15 We buried one poor chap in the Channel.
14.12.12. Reached Southampton in early morning. Disembarked in evening.
15.12.15 Arrived at Glasgow where we went to Bellahouston Hospital.
23.12.15 Spent a good Christmas Day.
(Editor: Rifleman Seabrook was subsequently posted to Egypt. Happily he survived the War)
]]>If you scroll back through the Blogs on this site you will see that we have been warning against Statin use and “the cholesterol myth” for many years. In more recent Blogs you will find evidence that reality about saturated fat, statins and cholesterol is beginning to dawn. It is not cholesterol that causes illness, but the oxidization of cholesterol. Oxidization is not caused by fats, or proteins, but by sugar, sweeteners, processed food (pasta turns to sugar in the body), endurance exercise, air pollution, stress, smoking, excessive drinking and much else that we really know is bad for us.
One commonly prescribed statin is Rosuvastin. According to “The Times” of 18th March, 2015, there are 1.8 million prescriptions of this one statin a year in England alone, costing £45.6 million. There may be a few people, whose health condition requires statin treatment, but for most it is a pointless and risky treatment. Now joining those reported in earlier Blogs is Sidney Wolfe, senior adviser on health research at the US advocacy group “Public Citizen”, who writing in the BMJ warns of the increased risk of type 2 diabetes: “There is increasing evidence that the drug also carries a higher risk of adverse effects” including diabetes, muscle damage and kidney problems. The success of Rosuvastin is attributed to marketing, the marketing of which (AstraZeneca’s brand name “Crestor”) as far back as 2003 was described in the “Lancet” as being pushed “too hard and too fast.”
In 2002 Professor John P. Cooke, one of America’s leading heart specialists, wrote, “Cholesterol itself is not bad. In fact, it is essential for life. Cholesterol is a building block for all cell membranes. It is also the precursor for sex hormones and other steroids that our bodies manufacture. It is only when cholesterol becomes oxidized that trouble begins.” (“The Cardiovascular Cure”, page 38). Research in 1992 established research that in terms of overall mortality lowering cholesterol worsens your prospects (e.g. Hacobs et al, “Circulation” 1992;86:1046-1060. Statins are shown to reduce/block co-enzyme Q10 and the redoubtable Dr Mercola links low cholesterol with violent behavior and aggression, depression, suicide, cancer, Parkinson’s disease an loss of heart elasticity.
So we should not be compromising our health with cholesterol lowering drugs, but addressing oxidization of cholesterol in our veins and arteries (all 100,000 miles).Patients with the highest levels of antioxidants in their bodies have the lowest incidence of coronary heart disease (Ross, “Atherosclerosis: An inflammatory disease”, New England Journal of Medicine, 340 (1999), 115-123 and please see Steinberg, “Antioxidants in the prevention of human artherosclerosis”, National Heart, Lung and Blood Institute workshop: September 5-6, 1991). Few antioxidants, unlike statins, carry any side-effects (a huge excess of vitamin C can make you rush to the lavatory). Antioxidant supplementation is essential for us all: including vitamins A, C and E, coenzyme Q10 and L-arginine. As you will guess, I particularly favour L-arginine. For more information please go to the ADNO page on this site.
]]>Research has shown that oxidation/free radicals are the underlying initiator of over 70 chronic diseases, including cancer and heart disease (Davies, “Oxidative stress: The paradox of aerobic life,” Biochem Soc Symp, 61 (1995), 1-31). I agree that blueberries are likely to help the body resist cancer: apart from the established impact of vitamin C on cancer blueberries rank high on the ORAC (Oxygen Radical Absorbance Capacity) Table.
I do, however, respectfully differ from Rochele in the implication that cholesterol is something that needs to be reduced. This smacks of the cholesterol myth. Even the USA has recently reversed the warning against ‘cholesterol laden foods’ (http://www.washingtonpost.com/blogs/wonkblog/wp/2015/02/10/feds-poised-to-withdraw-longstanding-warnings-about-dietary-cholesterol/)? A recent study (published BMJ’s Open Heart journal by the University of the West of Scotland - Zoë Harcombe et al), concludes that dietary guidelines relating to saturated fat/cholesterol adopted by British authorities in the early 1980s and still in use today are based on “very limited evidence”. The study states, “It seems incomprehensible that dietary advice was introduced for 220 million Americans and 56 million UK citizens given the contrary results from a small number of unhealthy men” and “Dietary advice does not merely need a review; it should not have been introduced.” Professor John P. Cooke says, “Cholesterol itself is not bad. In fact, it is essential for life. Cholesterol is a building block for all cell membranes. It is also the precursor for sex hormones and other steroids that our bodies manufacture. It is only when cholesterol becomes oxidized that trouble begins.” (“The Cardiovascular Cure”, page 38). The cholesterol myth is especially pernicious, because it is well established that low cholesterol relates to lower life expectancy (e.g. Hacobs et al “Circulation” 1992; 86:1046-1060).
Antioxidants are the key. Blueberries and many other foods are good antioxidant foods and the more diet includes ORAC foods the better. However, these days antioxidant supplements should be considered, including vitamins A, C and E, coenzyme Q10 and L-arginine. I am a disciple of L-arginine, which is for instance shown to increase in the ability of lymphocyte cells to neutralize target cells (Park et al, “Stimulation of Lymphocyte Natural Cytotoxity by L-Arginine,” The Lancet, 337 (1991), 645-646) reduce tumours reduction (Takeda et al, “Inhibitory Effect of L-Arginine on Growth of Rat Mammary Tumors …” Cancer Research, 35 (1975), 2390-2393, Feinman et al, “Tumor Necrosis Factor Is an Important Mediator of Tumor Cell Killing by Human Monocytes,” Journal of Immunology, 138 (1987), 635-640, Hibbs et al, “L-Arginine is Required for Expression of Activated Macrophage effector Mechanism…,”The Journal of Immunology, 138 (1987), 550-565, Kwon et al, “Inhibition of Tumor Cell…by Macrophage Derived Nitric Oxide,” Journal of Experimental Medicine 174 (1991), 761-767) and inhibit the progression of colon cancer (Yeh et al., “Effect of arginine on angiogenesis induced by human colon cancer: in vitro and in vivo studies”, Journal of Nutritional Biochemistry, 21(6), 538-543).
]]>The cholesterol myth rose on the flimsiest of foundations from the Framingham studies. Although given no publicity the one definitive finding, which ran against the underlying motivation of the studies, in Framing was that consuming saturated fat/cholesterol rich foods had no correlation to cholesterol levels in the body. Sadly the new guideline, whilst belatedly exonerating cholesterol rich foods from any health risk, still perpetuates the false beliefs that saturated fat is bad and causes cholesterol and that cholesterol is bad, when it is an essential part of our well being. It is oxidization of cholesterol in the arteries that is the true evil. There are many causes, such as sugar, trans fats, processed carbohydrates, but saturated fat is not implicated. What is more, insofar as saturated fat can be associated with cholesterol in the body, it is associated with type A particles in LDL, whereas type B particles most associated with being oxidized.
Also, most encouraging is the recent study (published BMJ’s Open Heart journal by the University of the West of Scotland - Zoë Harcombe et al), which concludes that dietary guidelines adopted by British authorities in the early 1980s and still in use today are based on “very limited evidence”. The study states, “It seems incomprehensible that dietary advice was introduced for 220 million Americans and 56 million UK citizens given the contrary results from a small number of unhealthy men” and “Dietary advice does not merely need a review; it should not have been introduced.” Again this is not the opening of the flood gates, because the newspapers, having reported this study then treated their readers to extensive advice against saturated fat, cholesterol and the study itself by saturated fat-heads, who still cling to the cholesterol myth.
The dam is beginning to show the first signs of bursting, but I do not think the war will be over by Christmas. The key to good health is, of course, anti-oxidant supplementation.
]]>Even the British Medical Journal recently published an article decrying the false link between saturated fat, cholesterol and CVD (http://www.bmj.com/content/347/bmj.f6340 ). In “The Times Magazine” of 24th May, 2014, there was a rare bit of good nutritional wisdom in mainstream media. Giles Coren, having just returned from two months of reviewing American eateries, opined that, “In Britain, we divide broadly into slim, wealthy, educated people who understand the basics of nutrition and eat relatively healthily, and poor, uneducated, fat people who do not even pretend to give a damn. In America, on the other hand, most people think they are on a diet. This is the land which (in the Fifties) first established the bogus link between the consumption of animal fat and unhealthy human body weight, and the idea still persists in 2014, with the result that almost all processed food (which combined with food consumed in restaurant and fast-food joints, comprises 90 per cent of the American diet) advertises itself as containing ‘0 per cent fat’, while listing under its ingredients many obesifying sugars that have been used as compensatory flavour enhancers. So the ‘healthier’ you eat, the fatter you get.”
I was prompted to write this article by the recent campaign for Quorn. As a vegetarian I like the fact that Quorn allows me to enjoy a meatless Shepherd’s Pie, but in the first advertisement of the recent campaign the wonderful Mo Farah is made to say, “Quorn Mince is a healthier protein source, because it is low in saturated fat.” No no, Mo, you are so so wrong! Quorn sales rose by 7% in the last year and by 25% in the USA “tapping into the new demand for healthier food amid concern about an American obesity epidemic.” (“The Times”, 22nd Jan., 2015). Neither obesity, nor CVD can be conquered by cutting saturated fat. Rather we need to cut consumption of sugar (this month associated with early puberty and breast cancer by the Harvard Medical School), processed carbohydrates and trans fats. The ill informed would urge you to cook your Quorn sausages in vegetable oil, but oils oxidize when heated unlike grandma’s trusted meat fats and butter. To that please add the new kid on the block, coconut oil, which is largely saturated fat and contains other healthy elements.
Sugar, processed carbs, trans fats and oxidized oils all create free radicals and trigger oxidization of type B LDL cholesterol particles (saturated fats are associated with type A particles in any case) in the arteries. What our Mo should bear in mind, especially as prolonged exercise itself creates free radicals, is that those with the least risk of CVD are those with the highest levels of antioxidants in their bodies (e.g. Ross et al., New England Journal of Medicine 340 (1999), 115-123 and Steinberg et al., National Hear, Lung, and Blood Institute Workshop 5-6, 1991). Reverting to the Quorn theme it should not be forgotten that meat is the highest source of the key antioxidant, L-arginine. For veggies it is impossible to achieve a minimum daily intake of L-arginine by ordinary diet (Professor Cooke gets nowhere near in his helpful dietary suggestions in “The Cardiovascular Cure”). I am sure that Mo takes a variety of supplements and so should we all. Cholesterol improves brain function and maybe when we have raised our levels we shall be able to see through the ‘cholesterol myth’.
]]>The preliminary conclusion is that the antibiotic impairs the liver ability to break down the statin drug leading to a dangerous build up of the drug in the blood.
50,000 older users of statins and clarithromycin, or azithromycin were studied. Of those taking clarithromycin 200 deaths and 175 admissions to hospital with severe kidney damage in the subsequent 30 days were noted. In the following 30 days the azithromycin group suffered 155 deaths and 122 serious kidney admissions. Of course, the study group was more prone to death and illness than average, but when the researchers adjusted the figures to allow for this it was found that the risk of fatality was increased by 43%.
Amit Garg is quoted as saying, “When you think about how commonly these drugs are prescribed, it suggests that tens of thousands of cases worldwide could be prevented. We thought these drugs would be OK, but actually that may not be the case. We showed there was an interaction. This group of statins weren’t that different from the first group, so we do need to be careful about interactions.”
Professor Weissberg of the British Heart Foundation (hopefully it will soon see the light about cholesterol) is quoted in “The Times” as saying that doctors are aware of the riosks associated with mixing clarithromycin and statins and usually chose on after the other. Can you see those flying pigs, Professor?
The evidence against statins mounts (please see earlier blogs, which set out much of this), but the key point is that statins primarily reduce cholesterol, but cholesterol is good and not bad. As Professor John P. Cooke says, “Cholesterol itself is not bad. In fact, it is essential for life. Cholesterol is a building block for all cell membranes. It is also the precursor for sex hormones and other steroids that our bodies manufacture. It is only when cholesterol becomes oxidized that trouble begins.” (“The Cardiovascular Cure”, page 38). As Dr McGee in “Heart Frauds” reviews the evidence showing the importance and benefits of cholesterol. For example the mortality of men with cholesterols under160 was 17% poorer than for men between 160 and 240 (Hacobs et al “Circulation” 1992; 86:1046-1060).
If you take arginine supplementation to reduce and reverse the oxidation of cholesterol you improve your immune system and probably wont need antibiotics at all, but, if you do, you can take them without concern.
]]>Cardiovascular therapies dominate generic prescribing in England, figures from the NHS Information Center show.
Drugs for cardiovascular disease (CVD) make up four of the five highest places among the top 10 most prescribed generic drugs
The thyroid treatment levothyroxine sodium is the only non-CVD (cardio vascular) treatment encroaching in the top five places.
Numbers of prescriptions for two proton-pump inhibitors (lansoprazole and omeprazole) are almost equal and scrape in to the tail end of the top 10, though if combined these two would be amongst the top three most prescribed generic drugs.
Top 10 most prescribed generic drugs
As you can see the most common proscription are the statin group.
Statins why do they actually bother?
Many of you will come across people who are hardly aware that statins are actually, in the long term, potentially dangerous. This list is taken for the NHS website, when you look at, it recommends that you talk to your GP about side effects, the list is long and nasty. I have yet to come across a person who was recommended statins (including myself) who actually had a discussion with their GP concerning the side effects, most people are wandering around oblivious to the affect that the recent headache, nausea, sore throat and hike in their blood sugar medications is down to the ‘beneficial’ use of statins. Its important to know that the headache and elevated blood pressure may well get you a repeat prescription for a couple of pain killers and Rampiril, because now you will have started down the dark slope of being medicated because you are on medication.
Common side effects
Although side effects can vary between different statins, common side effects (which affect up to 1 in 10 people) include:
nosebleeds
sore throat
a runny or blocked nose (non-allergic rhinitis)
headache
feeling sick
problems with the digestive system, such as constipation, diarrhoea, indigestion or flatulence (passing wind)
muscle and joint pain (see below)
increased blood sugar level (hyperglycaemia)
an increased risk of diabetes
Uncommon side effects of statins (which may affect up to 1 in 100 people) include:
being sick
loss of appetite or weight gain
difficulty sleeping (insomnia) or having nightmares
dizziness – if you experience this, do not drive or use tools and machinery
loss of sensation or tingling in the nerve endings of the hands and feet (peripheral neuropathy)
memory problems
blurred vision – if you experience this, do not drive or use tools and machinery
ringing in the ears
inflammation of the liver (hepatitis), which can cause flu-like symptoms
inflammation of the pancreas (pancreatitis), which can cause stomach pain
skin problems, such as acne or an itchy red rash
feeling unusually tired or physically weak
Rare side effects
Rare side effects of statins (which may affect up to 1 in 1,000 people) include:
visual disturbances
bleeding or bruising easily
yellowing of the skin and eyes (jaundice)
Muscle effects
Statins can occasionally cause muscle inflammation (swelling) and damage. Your doctor will carry out a blood test to measure a substance in your blood called creatine kinase (CK), which is released into the blood when your muscles are inflamed or damaged.
If the level of CK in your blood is more than five times the normal level, your doctor may advise you to stop taking the statin. Regular exercise can sometimes lead to a rise in CK, so tell your doctor if you have been exercising a lot.
Once your CK level has returned to normal, your doctor may suggest you start taking the statin again, but at a lower dose.
The Dark Side
Statin drugs are classified as pregnancy Category X medications, meaning they cause serious birth defects and should NEVER be used by a pregnant woman, or women planning a pregnancy. Shockingly, many physicians are still unaware of this serious risk and continue prescribing statin drugs to pregnant patients.
Statin drugs are one of the most commonly prescribed drugs in the US. One in four Americans over the age of 45 is now taking a statin drug, and few are properly warned about the related health risks, which include diabetes, premature aging, and heart failure, in the UK we are catching up fast on this number.
A recent meta-analysis of 72 trials, which involved a total of close to 160,000 patients, revealed that statin treatments significantly increased the rate of diabetes and liver damage.
Statin drugs interfere with a number of biological functions, including a central pathway for steroid management, which negatively affects all of your sterols, sex hormones, cortisone, and Coenzyme Q10, which is critical to the energy generation in every cell of your body.
If you’re taking a statin drug, it is absolutely CRITICAL that you also take a CoQ10 supplement, to limit the damage of the drug. This basic piece of biochemistry is unknown to most physicians.
What’s the alternative?
In 1997 Dr Rainer H Boger at Hanover School of Medicine in Germany performed a medical study of l-Arginine against Lovastatin (Mevacor). In the standard rabbit/cholesterol test (it’s easy to induce high cholesterol in rabbits via diet). In the rabbit test l-Arginine exceeded the results of the statin used by comparison. This study was published in Circulation the Journal of the American Heart Association August 1997. Study went on to show that L-Arginine also inhibited free radicals which statins cannot. If you add the results of the 10,000 peer reviewed medical papers on L-Arginine you will see that it also can be used for all of the common side effects associated with statin use as well.
Bottom line is I use ARK1 and ARK2 and achieve equal if not better results with none of the side effects or damaged caused by statins. It is also proven to normalise blood pressure and has been shown in studies to very effective in migraine headache.
I recommend ARK1 because it can be found in the blood stream 8 hours after ingestion. I feel the most important aspect is that Ark1 maintains the blood and lymphatic flow during the sleep cycle for the entire cycle. This I feel is crucial and at the moment, as far as research papers can be found, ARK1 is the most potent enduring formula now available.
If you read up on the net you will find that ARK1 and L-Arginine can often be used as a viable alternative to all of the 10 most common prescriptive medications offered on the NHS. Why take all 10 or three or four when you can take one with no side affects apart from increased health.
]]>
Cholesterol and the Pharmaceutical Industry's Biggest Secret
Shane Ellison, M.Sc.
A commonly held myth is that high cholesterol, especially LDL cholesterol, is a major risk factor for heart disease (known as atherosclerosis).
Thus, in a panicked attempt to prevent this pandemic killer millions of people are using cholesterol-lowering drugs. However, when we consider the scientific evidence it appears that the aforementioned myth is the antithesis.
Researcher Behar and associates found that in the low cholesterol group (total cholesterol below 160mg/dl) the relative risk of death was 2.27 times higher relative to those with high cholesterol.
The most common cause of death in the low cholesterol group was cancer while the risk of cardiac death was the same in both groups.
In support of their findings these researchers point out that previous studies found a higher increase in lung cancer when total cholesterol levels were maintained below 170 mg/dl.
4.The most widely respected medical journal, the Journal of the American Medical Association, published a study entitled: Cholesterol and Mortality. 30 Years of Follow-up from the Framingham study.
Shocking to most, this in-depth study showed that after the age of 50 there is no increased overall death associated with high cholesterol! There was however a direct association between low levels (or dropping levels) of cholesterol and increased death.
Specifically, medical researchers reported that CVD death rates increased by 14% for every 1mg/dl drop in total cholesterol levels per year.
In their analysis of 1,134 patients with heart disease they found that low cholesterol was associated with worse outcomes in heart failure patients and impaired survival while high cholesterol improved survival rates.
Additionally, their findings showed that elevated cholesterol among patients was not associated with hypertension, diabetes, or coronary heart disease.
Hence, those who think they are safe from heart disease due to lowering total cholesterol levels may want to seriously rethink their preventative efforts.
Sadly though, some of the most well-respected health practitioners, medical doctors, and herbalists in the world have fallen victim to pharmaceutical propaganda.
This can be seen by their often regurgitated, ill-thought out hypothesis that lowering cholesterol prevents heart disease.
Meanwhile, people continue to die (2700 people die every day from heart disease) while pharmaceutical companies enrich themselves with the sales of cholesterol-lowering drugs.
The CEO of Pfizer, makers of the popular cholesterol-lowering drug Lipitor, was compensated 33.9 million dollars last year (does not include the ten's of millions in stock options). This equates to 2.8 million per month, which is about $94,000 per day.
So, how does one successfully convince the entire U.S that each and every person should have the same cholesterol levels?
Easy, pharmaceutical companies work tirelessly to promulgate the cholesterol-lowering myth by conveniently citing supportive studies while burying the unsupportive.
As reported in the British Medical Journal, Uffe Ravnskov MD, PhD shows his results of a meta-analysis of 22 published controlled cholesterol-lowering trials.
He found that studies which showed to be supportive of low cholesterol were cited six times more often than those that were unsupportive and that unsupportive trials had not been reported since 1970!
Further, his research showed that those studies that were supportive of low cholesterol were due to bias on part of the researchers.
With 12 billion dollars worth of cholesterol-lowering drugs sold annually, the average American has become a cholesterol-lowering drug addict. Few users have given any thought to the potential negative side effects fo the drugs.
For instance, evidence from the cholesterol-lowering trial known as PROSPER showed that while Pravachol may have prevented 22 deaths from cardiovascular disease the benefit was negated by 24 deaths caused by cancer among those taking Pravachol.
Numerous medical journals have shown that cholesterol-lowering drugs significantly increase ones risk of suffering from not only cancer but also CoQ10 deficiency (paradoxically leads to heart disease), rhabdomyolysis, erectile dysfunction and loss of memory and mental focus.
Combined, these facts render America's best selling drug useless and in some cases deadly (make you wonder about the other less popular drugs). As such, they are among the pharmaceutical industries biggest secrets. You won't hear about them from your doctor, the media, or a pharmaceutical sales rep.
To circumvent blind addiction to cholesterol-lowering drugs, their deadly side-effects, wasted money, and finally, heart disease itself, Americans must understand the importance of cholesterol in the human body. Moreover, they must learn about natural medicine which rivals synthetic drugs and lifestyle habits that have been proven to prevent and treat heart disease.
As I said in the last news letter, what’s the alternative?
]]>People need continuous supplies of vitamin C, a water-soluble vitamin necessary for growth and development.
The excess amounts of vitamin C leave the body through urine. Getting continuous amounts of vitamin C helps with wound healing and general life repair. Vitamin C has antioxidant properties to block damage from oxidation that can lead to inflammatory conditions, heart disease and cancer. Vitamin C also protects against toxic chemicals and air irritants. Some people believe high doses of vitamin C can protect the body from colds and flu.
Vitamin E is considered a free radical fighter. Free radicals result from oxidation and cause genetic damage and cell death. The vitamin may help provide protection against heart disease and cancer. Some research has shown that people with higher levels of vitamin E have a lower risk of heart disease, according to the University of Maryland Medical Center. The vitamin may also help prevent some cancers. Adequate amounts of vitamin E prevent liver and kidney problems. Diabetics may benefit from vitamin E because many people with diabetes have low levels of antioxidants. The vitamin has been used and shown to help control blood sugar levels and cholesterol levels.
Beta-carotene belongs to a class of chemical compounds called carotenoids. Among many positive health benefits, carotenoids act as a precursor to vitamin A, so if you know about the benefits of vitamin A, you will completely understand the importance of beta-carotene.
Basically, when you consume foods or ingest supplements containing beta-carotene, it breaks down into vitamin A in your liver.
Beta-carotene is thought to possess many positive health benefits and in particular helps prevent night blindness and other eye problems.
It is effective in skin disorders (Retin A, the skin cream, is a modified Vitamin A), enhances immunity, protects against toxins and cancer formations, colds, flu, and infections. It is an antioxidant and protector of the cells while slowing the aging process.
It is postulated that natural Beta-Carotene aids in cancer prevention. It is important in the formation of bones and teeth. No vitamin overdose can occur with natural Beta-Carotene. It has been reported that beta carotene offers a notable measure of photo protection to individuals with porphyria. (Beta-Carotene helps to protect the eye and vision).
.
Magnesium
Magnesium helps control hundreds of chemical reactions in the body. It also helps regulate blood pressure, strengthen muscles and bones, keeps the immune system strong and supports cardiac and brain function
While too much magnesium is rare, too little magnesium in the body can interfere and or decrease the functioning of the systems and organs we need to work smoothly –namely the heart, brain, musculoskeletal, digestive and circulatory systems.
Low magnesium levels can manifest itself in any number of unexpected ways, contributing to muscle cramps, PMS, memory problems, heart irregularities, asthma, allergies and diabetes. It can even exacerbate SAD (Seasonal Affective Disorder) symptoms by inhibiting the conversion of tryptophan to 5-HTP, which can decrease the production of mood-stabilizing serotonin and melatonin on this vital mineral, particularly when it can be so easily managed.
Research has indicated that as many as 80% of us are in some way magnesium deficient, so supplementing it is an excellent way to support good health. Even if you maintain a good diet, stress, pollution and alcohol use plus OTC drugs can lead to magnesium depletion despite your best efforts.
Harry Elwardt, N.D., PhD.
“… A few grams of prevention is worth a ton of cure.”
Macrophages are one of the main phagocytic cells capable of destroying parasites. Once the parasite is ingested by these cells, they begin to produce nitric oxide (NO), a potent chemical that is toxic to these pathogens. In fact, NO related products are toxic to malaria, leishmania, trypanosomes, shistosome larvae. interferon-gamma (IFN-γ) activates the macrophage that produces the NO
http://www.itqb.unl.pt/~Metalloproteins_Bioenergetics/research.htm
Direct killing by cytokine-activated macrophages. TH1 (T Helper 1) cells generate a signal (IFN-γ). IFN-γ activates the macrophage. The macrophage can either secrete NO to destroy the pathogen or release the NO within its cytoplasm to directly destroy ingested pathogens (not shown). The arrow pointing from the parasite to the TH1 cell indicates that it is the presence of the parasite within the host that activates the TH1 cell.
Sobolewski P1, Gramaglia I, Frangos J, Intaglietta M, van der Heyde HC.
Bottom line
L-Arginine when available in suitable quantities and backed up by L-citrulline and supporting nutrition provides the ‘bullets’ or more appropriately ‘cannon balls’ to shoot the pathogen with.
The cure to the common cold is not boost your immune system, it is more a case of get in more ammunition! The immune system uses small puffs of NO gas to kill a virus, bacteria, pathogen or parasite before eating and destroying the pathogen. Such is the strength of NO that it is toxic to malaria. ARK1 and its two sister products ARK2 and the Purple Pill are the ultimate immune system booster.
Think of the pathogen ‘flu virus’ as an annoying fly or mosquito, the gas produced by the ARK1 is the strongest fly spray available!
]]>What you may not know is that the same research programme was repeated the following year, but with pure L-arginine. This time the results were inconclusive. Why was this? The answer is that Ark 1 is formulated/stacked to create maximum absorption and duration of effect. In the attached article the renowned Dr Roderick Lane explains why this is.
L-arginine is still the key, but without clever formulation you need a lot more of it for the same result.
]]>What is different about ARK 1?
Why is ARK1 (the L-arginine based ‘Pink Drink’) so important for resisting physical, structural and tissue ageing? Most of the research has been carried out on young athletes, because it is hard to find a group of over 60’s who want to be put through repetitive strain exercises and Wingate tests. Fatigue, muscle loss, lack of endurance, lack of physical flexibility are age related conditions. These ‘ageing’ conditions are only experienced by the young under extreme stress, which is why these tests are relevant and important. Throughout this paper you will find highlighted boxes, which identify exactly why each element in Ark1 is important for health, fitness and anti-ageing.
You will find many L-arginine based supplements and studies on the web, but in many ways Ark 1 stands out. The key is, of course, as with all supplements quality and formulation, more commonly referred to as ‘stacking': ARK 1 one uses the known nutritional elements in the correct absorption ratios thereby enabling the L-arginine to be better absorbed and to last longer in the cardiovascular system thereby producing maximum function from the smallest dose possible of this natural amino acid. ARK 1 also combines arginine-alpha-ketoglutarate and L-arginine in the formula together they act synergistically and improve nitrogen function. ARK 1 is unique in its formulation, because it has everything required and a few things more better to achieve maximum function and efficiency. The L-arginine in ARK 1 is derived from soya and the supplement is entirely suitable for vegetarians and vegans as are all Arkworld products. The formulation of ARK1 is subject to a renewable formulation patent.
Component overview and amino acid functions
Supplement Information: Per 10g Serving (2 servings per day) %RDA
Maltodextrin, Fructose, Citric Acid, Malic Acid, Beet Juice Powder
By Chief Executive Scientist Jeff Golini
Looking into the benefits of Arginine and/or Arginine-Alpha-Ketoglutarate, found in Arkworld Products in Scientific Literature
Additional information on basic uses of amino acids contained in ARK 1
L-Arginine over view
Arginine Alpha-Ketoglutarate (AAKG) is a popular ingredient in many cell volumisers. AAKG contains both Arginine and Alpha-Ketoglutarate. Arginine is a conditionally essential amino acid that has a number of vital roles in human biochemistry and has an important role in protein synthesis. Alpha-Ketoglutarate is another important biological compound, used by the body to help with the creation of usable energy from carbohydrates, fats and protein. It combines with ammonia to create glutamic acid, a precursor of glutamine. Our AAKG is produced at a ratio of 2:1 (Arginine: Alpha-Ketoglutarate).
Benefits
The Alpha-Ketoglutarate compound helps improve the delivery of L-arginine in metabolic pathways.
ARK1, as an anti-ageing tool, is critical as it increases blood flow and volume to all areas of the body both muscle, sinew, skin and individual cells. Increased delivery of blood means increased delivery of the nutrients that generate healthy tissue. NO (arginine derived nitrous oxide) is a very powerful vasodilator that increases the intensity and duration of the "pump" which is gained when working out (usually after heavy weights). Most AAKG users experience a visible increase in vascularity and pump. Our AAKG is produced at a ratio of 2:1 (Arginine: Alpha-Ketoglutarate).
Studies
There are several scientific research articles that indicate the benefits of either arginine-alphaketoglutarate or alpha-ketoglutarate alone in athletic performance. The following is just a sampling of some of the more recent articles.
1). Arginine alpha-ketoglutarate, Creatine, amino acids, and mediumchain triglycerides on endurance and performance. College of Kinesiology, University of Saskatchewan, Saskatoon, SK, Canada.
Arginine Alpha-Ketoglutarate (A-AKG) found in ARKWORLD’S ’ARK 1′ product is a precursor for nitric oxide production and has, as already noted, the potential to improve blood flow and nutrient delivery to the muscles, which in turn helps to increase muscle mass, strength and power from supplementations such as Creatine. This study compared a dietary supplement of Creatine, Glutamine, Taurine, branchedchain amino acids and medium-chain triglycerides with Arginine Alpha–Ketoglutarate and one without, on exercise performance and body composition. Thirty-five men (approximately 23 years of age) were randomized and studied in both situations for 10 days.
As we age we tend to lose muscle mass, muscle flexibility and reduced endurance. As you can see ARK1 can increase endurance. Body composition, muscle endurance (bench press), and peak and average power (Wingate tests) were measured before and after supplementation. - Bench-press repetitions over 3 sets were increased significantly using Arginine Alpha-Ketoglutarate along with Creatine as opposed to using Creatine by itself
Peak power and average power were also significantly increased over the time by including Arginine Alpha Ketoglutarate.
The group of men combining Arginine Alpha-Ketogluterate (A-AKG) with the other ingredients such as Creatine in the dietary supplement also had a greater increase in total body mass opposed to those men that were not taking Arginine Alpha-Ketogluterate, with no significant changes in lean-tissue or fat mass.
The combined nature of the formula increase physical output without extra physical training or fitness classes. These results suggest that using Arginine Alpha-Ketogluterate found in Arkworlds Ark 1 supplement in combination with Creatine improves upper body muscle endurance and improves peak power output on repeated Wingate tests at a much greater level than using Creatine or other supplements by themselves.
Interesting and almost incredible results!
Cellular regeneration is a key factor of muscle density, skin repair and rejuvenation as well as flexibility. The combination of Arginine and Arginine Alpha-Ketoglutarate with Micro Nutrition is a special formulation that is exclusive to Arkworld that also has the ability to increase the cellular healing and delivery mechanism within the body, which can add even greater to the results that an athlete may experience.
Overview
Alpha-Ketoglutarate
Arginine Alpha-Ketoglutarate (AAKG) is a popular ingredient in many cell volumisers. AAKG contains both Arginine and Alpha-Ketoglutarate. Arginine is a conditionally essential amino acid that has a number of vital roles in human biochemistry and has an important role in protein synthesis. Alpha-Ketoglutarate is another important biological compound, used by the body to help with the creation of usable energy from carbohydrates, fats and protein. It combines with ammonia to create glutamic acid, a precursor of glutamine. Our AAKG is produced at a ratio of 2:1 (Arginine: Alpha-Ketoglutarate).
Benefits
The Alpha-Ketoglutarate compound helps improve the delivery of L-arginine in metabolic pathways.
NO (Arginine derived nitric oxide) is a very powerful vasodilator that increases the intensity and duration of the "pump" which is gained when working out (usually after heavy weights). Most AAKG users experience a visible increase in vascularity and pump. Ark’s AAKG is produced at a ratio of 2:1 (Arginine: Alpha-Ketoglutarate).
Studies
2). Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men.
Exercise and Sport Nutrition Laboratory at the Center for Exercise, Nutrition, and Preventative Health Research, Department of Health, Human Performance, and Recreation, Baylor University, Waco, Texas, USA.
OBJECTIVE:
We evaluated the pharmacokinetics, safety and efficacy of L-arginine Alpha-Ketoglutarate (A-AKG) found in ARKWORLD PRODUCTS in trained adult men.
METHODS:
Subjects participated in two studies that employed a randomized, double-blind, controlled design.
In study 1: Ten healthy men (30-50 years of age) fasted for 8 hours and then ingested either 4 grams of time-released or non-timed-released Arginine Alpha Ketoglutamate( A-AKG). Blood samples were taken for 8 hours after A-AKG ingestion to assess the pharmacokinetic profile of L-arginine. After 1 week the alternative supplement was ingested.
In study 2: In a placebo controlled study, 35 resistance-trained adult men (30-50 years of age) were randomly assigned to ingest 4 grams of Arginine Alpha-Ketoglutamate three times a day for a total of 12 grams daily. Participants performed 4 days of periodical resistance training per week for 8 weeks. At the beginning of the study, at the 4th week and at the 8th week of supplementation the following tests were performed: clinical blood markers, one repetition maximum bench press, isokinetic quadriceps muscle endurance, anaerobic power, aerobic capacity, total body water, body composition, and psychometric parameters tests. Data were analyzed by repeated measures analysis of variance.
RESULTS:
In study 1: Significant differences were observed in plasma Arginine levels in subjects taking non-timed – release and timed-release Arginine Alpha-Ketogluterate.
In study 2: Significant differences were observed in the A-AKG group for bench press, Wingate peak power, blood glucose, and plasma Arginine.
CONCLUSION:
The ‘Stacked’ delivery mechanism ensured increased blood flow and oxygen delivery for up to eight hours. Most arginine formulas last no longer than an hour. This implies that ARK1 is eight times more affective than other popular supplements. Arginine Alpha-Ketogluterate (A-AKG) found in Arkworld’s Ark 1 supplementation appeared to be safe and well tolerated, and positively influenced the bench press and Wingate peak power performance.
Overview
Ornithine Alpha Ketoglutarate
L Ornithine Alpha Ketoglutarate (OAKG) is a strong lean tissue building formula designed for the serious athlete.
OAKG increases endurance, energy and lean mass, whilst slowing down fatigue, catabolism and the build up of unwanted fat. Add to this its ability to speed up recovery time and you can see why this is one of the most popular choices for sports people world-wide.
L Ornithine Alpha Ketoglutarate is a nutritional supplement developed to help improve the athletic performance of athletes and sports persons. Many athletes and bodybuilders have reported extremely favourable improvements in decreasing the recovery time after surgery or injury.
This remarkable ingredient is producing such excellent results that it is now used in France after surgery in order to improve healing times.
TESTS
3). Ornithine alpha-ketoglutarate as a potent precursor of Arginine and Nitric Oxide: a new job for an old friend.
Biochemistry Laboratory, Htel-Dieu Hospital-AP-HP and Laboratory of Biological Nutrition EA 2498, School of Pharmacy, Paris 5 University.
Ornithine Alpha-Ketoglutarate (OKG), also used in the formulation process of Arkworld products, is a salt formed of 2 molecules of Ornithine and 1 part Alpha-Ketoglutarate. Its administration improves nutritional status in the chronically malnourished, for example in the extremely elderly and acutely malnourished patients (especially burn and trauma patients). There is evidence that OKG activity is not the simple addition of the effects of Ornithine and Alpha-Ketoglutarate, because the presence of both moieties is required to induce the generation of key metabolites such as glutamine, proline, and L-arginine, whereas this does not occur when one or the other is given separately.
This observation is related to the fact that the main feature of Ornithine at the whole-body level is that it is metabolized through the Ornithine aminotransferase-dependent pathway, whereas the simultaneous administration of Ornithine and Alpha-Ketoglutamate saturates this pathway, diverting Ornithine towards metabolism into Arginine as found in Arkworld’s Ark 1.
For years, OKG activity has been associated with its ability to induce the secretion of anabolic hormones, such as insulin and Human Growth Hormone, and to increase glutamine and polyamine synthesis. Recent studies using chemical inhibitors of Nitric Oxide Synthase (NOS) suggest that NO (nitric oxide) derived from Arginine is involved in OKG activity.
Ornithine Alpha-Ketoglutarate (OKG)administration improves nutritional status in the chronically malnourished, for example in the elderly and acutely malnourished patients (especially burn and trauma patients). The formula is show to have remarkable regenerative abilities on traumatized skin and tissue.
In conclusion, this activity of Arginine Derived Nitric Oxide that can be produced from the Arginine and Arginine Alpha Ketogluterate found in Arkworld products is therefore highly effective as a supplement for athletes. The increase of the anabolic hormones such as insulin and human growth hormone produced from taking Arginine and A-AKG not only increases training performance in athletes, but also can help to increase blood flow, muscle mass, the post training healing process and recuperation along with endurance and its Anti-Aging properties as well. Something that all athletes need and look for!
Overview
Citrulline Malate
Citrulline Malate is a unique combination of the amino acid L-citrulline and the organic salt malate that offers athletes a potential method of improving performance, delaying fatigue and accelerating recovery. It is particularly useful for people involved in high intensity exercise such as weight lifting and sprinting.
They is a great deal of talk in the health and beauty world concerning ‘toxins’, but what many do not realise is that these toxins are the by-products of normal physiological function. Some of them, such as lactic acid, are used in the cancer cell generation process. Citrulline acts to remove endotoxins such as lactic acid build up and ammonia, by acting as an intermediary in the Urea Cycle. Elimination of these chemicals at a cellular level is a critical factor in health and longevity. Citrulline also aids in the removal of other toxins, besides lactic acid and ammonia, which are by-products of intense physical activity, such as protein metabolism and catabolic states. Unfortunately, these by-products can seriously hamper exercise performance, but Citrulline can go some way to reducing their impact on performance and overall harmfulness.
Citrulline Malate can be used with Taurine to produce excellent pump and vascularity.
4). Pharmacokinetics of Arginine and related amino acids found in Arkworld products.
Clinical Chemistry Laboratory, Htel-Dieu Hospital, and Laboratory of Biological Nutrition EA 2498, Faculty of Pharmacy, University Paris 5 Ren Descartes, Paris 75006, France.
Arginine (ARG) and its related amino acids (AAs) Ornithine (ORN) and Citrulline (CIT) find a range of applications as dietary supplements in subgroups of healthy subjects (e.g., bodybuilders) and patients with acute or chronic malnutrition. These AAs appear to be well utilized in humans with, in general, a rapid return of blood concentrations to basal values and low absolute and relative excretion in urine. Based on published data for the maximum observed plasma concentrations (Cmax) after administration of doses in the range 5 to 10 grams, CIT (found in Arkworld’s Ark 1) was shown to present relatively better absorption and systemic bioavailability than ARG or ORN and add greatly to the absorption process.
Comparison of these studies further indicates that CIT has higher bioavailability than ORN. The pharmacokinetics and metabolism of these AAs are modified by the co-administration of a salt such as Alpha-Ketoglutarate that modifies AA metabolism, as has clearly been demonstrated for ornithine alpha-ketoglutarate. Concomitant administration of a meal leads to a 15- to 30-min delay in Cmax. Finally, data from various pharmacokinetic studies together with basic physiology and biochemistry indicate that ARG is a net urea producer and ORN has a nitrogen-sparing effect, whereas CIT is neutral.
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In conclusion, athletes, bodybuilders and sports people are always looking for increased performance and for better results from their chosen field. Using Arginine and Arginine Alpha Ketogluterate combined with Micro Nutrition found in the exclusive Arkworld products, as appear above can significantly increase that performance and results that they are looking for.
As the sports and athletic world continue to find more advanced ways to succeed to a greater extent and increase their overall performance and results, one thing is for sure; the revolutionary discoveries to date that are behind the ARKWORLD PRODUCTS make them an incredible addition to any athletes training program and a must to stay ahead of the competition!
Overview
L-glutamine
Glutamine is a key amino acid required by every muscle in the body, and is one of the most important building blocks in forming the proteins that maintain cellular health and tissue repair. Glutamine is found in varying amounts in most meat and fish and to lesser extent in vegetables and pulses. Anyone involved in high intensity training programmes designed for hypertrophy may find Glutamine a beneficial supplement.
The body is able to manufacture L-glutamine in small amounts, but the greater part of it must come from the diet, or supplementation. It is required for hypertrophy and also plays an important role in repairing damaged tissue.
Ageing is actually an endurance sport: consider how far you have walked in your entire lifetime - twice, three times around the world? Glutamine is considered useful to anyone undergoing training for endurance sports, such as long distance running or cycling, and can help to reduce the incidence of cramps caused through repetitive strain. Because Glutamine can help in this regard. It is also recommended as a natural alternative to chemical painkillers for elderly people, who suffer from cramps and regular muscle pain.
L-leucine
L-leucine is an essential amino acid that is broken down into fat structures. Though an essential amino acid it cannot be made by the human body and, therefore, must be consumed through nutition. It can be found ins nuts, brown rice and whole wheat bread products or dietary supplements. In total, L-leucine is around 8% of the total amino acid count in your body's protein structures. Also, It is, or should be, the fourth most concentrated amino acid in your tissue.
As one of the three essential BCAAs, L-leucine is essential to your basic health. The primary athletic functions of L Leucine are:
Helps preserve lean tissue.
Supplies your body with energy when under stress (i.e. when performing athletic activity).
Preserves muscle glycogen (glucose which is stored in the muscle tissue used to power your movements).
Maintains nitrogen balance.
Enhances mental clarity when performing intense physical exercise.
In a nutshell the effects of L-leucine in the diet are profound. It is the strongest of the BCAAs and is also what is known as a "limiting nutrient". This means you must have enough L -Leucine in proportion to other amino acids in order for your body to make full use of what you eat!
Building blocks and regeneration of tissue is key to the human physiological process and anti-ageing is no exception to this. The older we get the more we need the regenerative process. If you don't have enough L-leucine in your diet your body will not be able to make use of the protein that you give it, regardless of how much protein you consume. More importantly, unless you have enough L-leucine in your diet the money you spend on quality food and supplements could be wasted. This actually means that the consumption of most straight protein supplements is actually a non-beneficial process as they will only be utilised as food in ratio to the L-leucine content of the body, most being expended as basic fuel and not used as building blocks.
Over View
L-valine essential amino acid
L-valine is a branched-chain amino acid (BCAA) that works with the other two BCAAs, isoleucine and L-leucine, to promote normal growth, repair tissues, regulate blood sugar, and provide the body with energy. Valine helps stimulate the central nervous system, and is needed for sharp and acute mental function.
Essential Amino Acids (EAA's) are required in order to build new tissue and help with cellular repair, which takes place when muscles are recovering. Getting the right amount within a diet helps athletes to improve their physique and also recover more quickly from exercise. The main essential amino acids required by the body are L-eucine, L-isoleucine, L-valine, L-lysine, L-phenylalanine, L-threonine, L-histidine, L-methionine and L-tryptophan. These can be found in small quantities in natural foods.
We require all these different essential amino acids as part of our diet for a number of reasons, including cellular repair, but they are also required in order to get the most out of protein rich foods. If you do not get enough essential amino acids in your diet, the body will not extract the maximum nutrients from protein sources, and the calories in the protein will be stored as fat. The requirement for a balanced number of amino acids in the diet is referred to as 'limiting protein utilisation'.
A deficiency of valine may affect the myelin sheath covering of the nerves, and cause degenerative neurological conditions. A good supplement will contain essential amino acids in the correct ratios. This will improve their uptake in the body and provide maximum nutritional benefit. Increasing the intake of essential amino acids will allow athletes to train at a higher intensity for longer thanks to the improved recovery offered by balanced nutritional intake.
Over view
L-cysteine
L-cysteine is an amino acid that is closely related to Cystine. Cystine contains sulphur and is formed by two molecules of L-Cysteine. L-Cysteine is also a sulphur containing amino acid. It is used to manufacture L-glutathione and L-taurine.
L-cysteine is a non-essential amino acid, meaning it can be synthesized by humans. Cysteine is found in many high protein foods, including chicken, pork, eggs, milk, cottage cheese, garlic, granola and onions.
Benefits of L-cysteine
L-cysteine is beneficial in numerous ways. It is important in detoxification and in the formation of skin, as well as the repair of hair and nail tissue. It is used in producing antioxidants and protects the brain and liver from damage due to the consumption of alcohol, drugs and cigarette smoke. L-cysteine helps defend against harmful toxins and protects the body from damage caused by radiation.
Other benefits include reducing the effects of ageing. It also promotes healing of severe burns, fat burning and helps build muscle. Furthermore, L-cysteine promotes the activity of white blood cells. There are numerous other benefits including the effectiveness in treating bronchitis, angina and acute respiratory distress. L-cysteine helps to maintain optimal health and enhances immune system function.
Cysteine Bodybuilding
Bodybuilders’ immune systems are often compromised due to the amount of stress put on the body by performing strenuous endurance exercises. For this reason, supplementing with L-cysteine is recommended.
L-cysteine is effective in building lean muscle tissue since it is a precursor to Taurine. It is important in detoxification (remember the harmful nature of lactic acid build up) and in skin repair. Cysteine is a key player in the flexibility and quality of your skin, hair and nails. When blood glucose levels are low, L-cysteine is effective in producing energy by converting glucose. This may help to prevent the breakdown of muscle tissue and enhance endurance in bodybuilding.
L-isoleucine is one of the branched chain amino acids (L-isoleucine, L-valine, and L-leucine) and is classified as an essential amino acid. As already noted, this means the body cannot manufacture L-isoleucineand so must acquire it nutrition or supplementation. An average adult male’s daily requirement is 10 mg per kg of body weight.
L-isoleucine is commonly used in parenteral and enteral nutrition. It is used in combination with the other branched chain amino acids to improve the nutritional status of patients with hepatic diseases. Isoleucine is actually broken down for energy within the muscle tissue. Is also keeps energy levels stable by helping to regulate blood sugar; a deficiency of isoleucine produces symptoms similar to those of hypoglycaemia, which may include headaches, dizziness, fatigue, depression, confusion, and irritability.
BCAAs serve as important fuel sources for skeletal muscle during periods of metabolic stress; BCAAs may promote protein synthesis, suppress protein catabolism (muscle breakdown) and serve as substrates for gluconeogenesis. BCAAs are catabolised in skeletal muscle, stimulating the production of L-alanine and L-glutamine, among other substances.
The Up Regulation of L-alanine as a result of L-Arginine use.
L-alanine is a non-essential amino acid and plays a crucial role as a building block of important proteins.
Mostly synthesised by the muscle cells from lactic acid it is considered the most important nutrient for the amino acid metabolism in the blood together with L-Glutamine. Once synthesised L-alanine is absorbed via the liver and converted to a pyruvate. This compound is critical for the production of glucose and hence blood sugar management.
L-alanine supplements are therefore often used in cases of hypoglycaemia to prevent the organism from suffering low blood sugar or insulin shocks. They enable rapid energy delivery by stimulating the immediate release of glucose into the blood stream.
Other important functions of this amino acid are the support of the immune system and prevention of kidney stones (often associated with high protein compound use). L-alanine is thus often as a remedy in orthomolecular medicine.
Poor nutrition, a low protein diet, as well as stress- life, environmental factors, training schedules and exercise are stressful and can all cause an insufficiency of L-alanine. Such shortfalls should be compensated with dietary supplements with a level of urgency. Muscle endurance and strength may otherwise adversely affected and ongoing muscle atrophy (shrinkage), fatigue or faintness may result. When dosed appropriately however, L-alanine can be an effective nutrient supporting an intensive training regime and achieve effective muscle growth.
Athletes, in particular, have a much larger need to supplement their amino acids in order rapidly to build muscle mass. They usually consume protein powder before and after training in order to make the protein rapidly available in the blood stream enabling the body to repair and grow its muscles. They should also include certain foods in their diet, which have high concentrations of L-alanine and other amino acids in order to guarantee an ample supply of these for them vital nutrients.
L-alanine is a critical player in the body’s protein biosynthesis and has certain regulatory functionality. Muscle protein consists of approximately 6% of L-alanine. 30% of the L-alanine in the blood is synthesised by muscle, which demonstrates its importance to the overall metabolism. The L-alanine is absorbed from the blood in the liver and then converted to pyruvate. This enables a faster and more effective supply of energy when it is needed so that the body can perform longer at increased levels of intensity. Athletes therefore often supplement L-alanine in order to attain personal goals.
Other important tasks of this non-essential amino acid are the support of the immune system and prevention of kidney stones. These stones can be produced by the body as a result of coalescence of insoluble toxic compounds, which L-alanine is able chemically to neutralise.
L-alanine may therefore be used preventatively against kidney stones by individuals with a material family history. Also, kidney stones are a common problem for muscle developers due to the high loading of protein supplements.
L-alanine is also an important reactant for glucagon because it will stimulate its production when he blood sugar is too low. Additionally, it will support the generation of glucose from other amino acids.
Studies have shown that prostate fluid has a high concentration of L-alanine may therefore protect the prostate gland itself from an irregular enlargement. A symptom of this is usually severe pain and problems during urination. This can usually be reduced by the consumption of dietary supplements containing L-alanine.
It is therefore assumed that L-alanine can reduce the swelling of the gland’s tissue and even be used to treat prostate cancer.
The proteinogenic amino acid L-alanine has been successfully used to treat certain illnesses and is therefore used often in orthomolecular medicine. In addition to its ability positively to influence blood sugar it is also used frequently to prevent prostate cancer. Several studies have shown that L-alanine also stimulates the immune system, reduce inflammation and therefore helps to balance and stabilise the organism as a whole.
A study showed in 2002 that there is an interrelationship between L-alanine and the secretion of insulin by the pancreas. When allowed to react with glucose it leads to an increased production and excretion of glucose therefore positively influencing diabetes. The metabolism of glucose is improved overall and symptoms can be reduced or eliminated altogether. This reduces possible complications of secondary conditions resulting from diabetes, significantly improving patients’ quality of life.
A separate study demonstrated that the supplementing of L-alanine increases physical fitness when combined with exercise and protects from cardiovascular disorders. Over 400 individuals were asked to consume L-alanine supplements or placebos and the former group was shown to perform significantly better at exercise whilst displaying lower fat readings in the blood.
L-alanine plays a significant role in several metabolic processes and in regulating blood sugar. It can therefore be used not only against acute low sugar shocks, but is also it is able to stimulate insulin excretion in the pancreas and in doing so significantly improve the metabolism of glucose over longer periods of time. Other functions of this proteinogenic amino acid are the support of the ability to perform physically and build muscle mass. L-alanine supplements are therefore popular with athletes who are thus able to achieve increased performance.
L-alanine can further contain the uncontrolled growth (cancer) of the pancreatic tissue and is thus used to treat both prostate cancer itself as well as its symptoms. Please see for instance:
Disclaimer: All information contained in this document was obtained form open sources freely available on the internet. The ingredients and prices of the products may vary from time to time. The above information is provided solely as a guide to the genuinely held belief in these products, and is not intended as a substitute for advice from your doctor or other health care professional, or for any information contained on or in any product label, guidance, or packaging. The products and the claims made about specific products in this document have not been evaluated and approved by Arkworld, or the United States Food and Drug Administration, or any other like administrative body in any country. The products themselves are approved for sale in the USA and the UK, but the products are not approved as medicines to prevent, diagnose, treat, or prevent disease. You should not use the information on this site for diagnosis or treatment of any health problem or for taking of any medication or other treatment. You should consult your doctor or other appropriate healthcare professional before commencing any therapy, diet, exercise or course of food/nutritional supplements, or medication, or if you have any reason to think you have any problem with your health.
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Whilst it is good to be fit, it is a possibly fatal error to confuse fitness and good cardiovascular health. That is why more athletes than you might imagine succumb to CVD (see for instance Dr Harry Edwardt http://www.youtube.com/watch?v=MK_3kILU9Ug). Exercise does you good in reducing obesity, triggering release of Nitric Oxide and generally stimulating bodily functions. On the downside it generates oxygen free radicals. The more extreme/prolonged the exercise the more free radicals are released in the body and the more oxidation occurs in the arteries. Free radicals are harmful because they lack an electron and steal one from other atoms in the body setting up a possible chain reaction. Research has shown that oxidation/free radicals are the underlying initiator of over 70 chronic diseases, including heart disease (Davies, “Oxidative stress: The paradox of aerobic life,” Biochem Soc Symp, 61 (1995), 1-31).
The ideal is therefore to exercise in reasonable moderation and simultaneously to minimize oxidation by use of antioxidants, such as vitamin C, vitamin E and co-enzyme Q10. Most important of all antioxidants when it comes both to CVD and exercise is Nitric Oxide, which the body creates from the natural amino acid, L-arginine. Arginine Derived Nitric Oxide carries an extra electron and can therefore neutralize free radicals. It can resist and reverse oxidation in the arteries. Antioxidants allow you to reap the considerable benefits of exercise while minimizing the harmful effects. What is more, L-arginine supplementation can actually improve sporting performance/training endurance (http://www.sciencedaily.com/releases/2010/08/100826104137.htm). Another possible bonus is that a fascinating research paper (Jobgen et al, Journal of Nutrition, Feb 2009, 139(2): 230-37) on dietary induced obese (DIO) rats shows that Arginine supplementation reduces weight gain, reduces dangerous white fat and enhances skeletal muscle and brown fat. One last tip: if you are a bodybuilder keep your protein at least an hour away from your L-arginine – they each reduce the absorption of the other in the body.
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Beautiful Jewels,
Greeted us at her flat…
We all had a Pink Drink and enjoyed a good chat.
Pinky + Perky was this fruity Pink Drink…
Try some today and see what you think!
This miracle molecule will benefit you….
Better blood flow…more energy too…
No end to the overall health this product will do….
If your libido is lacking…
You know what to do…
Reach for the tub..
And you’ll be.. lovin’ it too!!!
Viagra is old school!!!
The news is out…
“Mine’s a Pink Drink”
You’ll hear the men shout.
To sum it all up
As there is no doubt…
“ARKWORLD IS THE FUTURE”
(The jury’s out)
BUY SOME TODAY
Before it sells out!!!
If “Heart Frauds” has got you thinking it has done its job. Conventional thinking about cardiovascular disease is upside down at present. As you will have seen from chapters 5 and 6 the cholesterol theory is totally mistaken and lower cholesterol equates to lower life expectancy. You should urgently review your use of statins, which primarily lower cholesterol. Cholesterol is good and vital to health, rather it is oxidation of LDL cholesterol by free radicals that causes blockage in the veins and arteries and is so harmful. Don’t avoid cholesterol, avoid the causes of oxidation of cholesterol.
Apart from being pointless for most people statins also have many adverse effects. Even the previously orthodox “Times” on 15th July carried an article reporting, “Over the same period, evidence shows that one person in40 on the drugs [statins] will develop a statin-induced cataract, around one in 100 will have liver problems, and one in 400 will develop kidney failure. Other side effects include a raised rosk of diabetes, acute muscle aches, fatigue, depression and erectile dysfunction.” Next to it was an article on Co-enzyme Q10 (CoQ10) quoting Dr Peter Langsjoen, cardiologist/fellow of American College of Cardiology, “Statins are a potent poison that block rather than enhance the bodiy’s cellular processes and have other side-effects such as memory loss and muscle weakness. There is no evidence statins have any benefit on mortality rates for women or for anybody over the age of 65. My hope is that, as more evidence emerges, people will ask themselves: ‘Why am I taking this expensive pill?’ and take CoQ10 instead.”
One of the main contributors to inflammation damage in the arteries is Lipoprotein(a) (LP(a)). It is a natural repair element in the body, but when inflammation develops it can overwhelm natural healing mechanisms. Dr Sinatra et al., write in “Reverse Heart Disease Now” (page 41): “Unfortunately, most cardiologists do not test for Lp(a). Most patients who see us for recurrent or inoperable angina have an elevated (and previously unrecognized) Lp(a) level. This explains why their bypass grafts close down and why their arteries renarrow following angioplasty. Studies show a connection between high Lp(a) and poor outcomes following bypass surgery or angioplasty, and continued problems among individuals with unstable angina and a background of heart attack.” Dr Sinatra et al. note, “Moreover, cholesterol-lowering statin drugs compound the problem. They may increase Lp(a).”
So statins increase Lp(a) and block co-enzyme Q10 as sadly does advancing age. Dr Loius Ignarro (one of the Nobel Laureates for his work on L-arginine) writes, “Research points to the use of CoQ10 as a supplement for the treatment of such heart problems as: Angina pectoris (heart pain)….” (NO More Heart Disease” pp 211-212).
In you shoes I should consider ditching the statins, I should take at least 4 scoops and probably 6 of Pink Drink per day (an hour away from protein intake – + at least one scoop before tennis and say another in your water), a large amount of CoQ10 supplements (Ark2 + maybe some cheap ones as well) and take large doses of high quality vitamin C (with bioflavonoid) and I mean about up to 10,000 mg per day. Vitamin C is a powerful antioxidant and it combats excess Lp(a).
For your further delectation I attach my latest monograph on Arginine.
Lunch would be lovely – Mondays, Tuesdays and Thursdays are good for me.
Best wishes,
Charles
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